Overview

  • Product name
  • Description
    Mouse polyclonal to PDE9A
  • Host species
    Mouse
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-533 of Human PDE9A (NP_001001567.1).

  • Positive control
    • PDE9A transfected 293T cell line; HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab168432 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 68 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • Function
    Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.
  • Tissue specificity
    Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate.
  • Sequence similarities
    Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily.
  • Domain
    Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
  • Cellular localization
    Cytoplasm. Endoplasmic reticulum; Cell projection > ruffle membrane. Cytoplasm > perinuclear region and Cell projection > ruffle membrane. Cytoplasm > perinuclear region. Golgi apparatus. Endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5''-cyclic phosphodiesterase 9A antibody
    • cGMP specific 3' 5' cyclic phosphodiesterase type 9 antibody
    • FLJ90181 antibody
    • High affinity cGMP-specific 3'' antibody
    • High-affinity cGMP-specific 3'5'-cyclic phosphodiesterase 9A antibody
    • HSPDE9A2 antibody
    • OTTHUMP00000109399 antibody
    • PDE 9A antibody
    • Pde9a antibody
    • PDE9A_HUMAN antibody
    • Phosphodiesterase 9A antibody
    • phosphodiesterase PDE9A21 antibody
    see all

Images

  • Immunofluorescence analysis of HeLa cells labeling PDE9A with ab168432 at 10µg/ml.
  • All lanes : Anti-PDE9A antibody (ab168432) at 1 µg/ml

    Lane 1 : PDE9A transfected 293T lysate
    Lane 2 : Non-transfected 293T lysate

    Lysates/proteins at 15 µl per lane.

    Predicted band size: 68 kDa

References

ab168432 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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