Anti-PDGFR alpha antibody (ab124392)
Key features and details
- Rabbit polyclonal to PDGFR alpha
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-PDGFR alpha antibody
See all PDGFR alpha primary antibodies -
Description
Rabbit polyclonal to PDGFR alpha -
Host species
Rabbit -
Tested Applications & Species
See all applications and species dataApplication Species IHC-P Human
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Immunogen
Synthetic peptide corresponding to Human PDGFR alpha aa 1035-1053 conjugated to keyhole limpet haemocyanin.
Sequence:cGKRNRHSSQTSEESAIETG
Database link: P16234
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at +4°C. Do Not Freeze. -
Storage buffer
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 99% Tris glycine, 0.88% Sodium chloride -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab124392 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
| Application | Species |
|---|---|
| IHC-P |
Human
|
| All applications |
Rat
Rabbit
Horse
Chicken
Cow
Dog
Pig
Xenopus laevis
|
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | (2) |
1/100.
|
| Notes |
|---|
|
IHC-P
1/100. |
Target
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Function
Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity. -
Tissue specificity
Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue. -
Involvement in disease
Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA). -
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 395509 Chicken
- Entrez Gene: 442860 Dog
- Entrez Gene: 5156 Human
- Entrez Gene: 100627123 Pig
- Entrez Gene: 25267 Rat
- Omim: 173490 Human
- SwissProt: P16234 Human
- SwissProt: P20786 Rat
see all -
Alternative names
- Alpha-type platelet-derived growth factor receptor antibody
- CD140 antigen-like family member A antibody
- CD140a antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDGFR alpha antibody (ab124392)
ab124392, at 1/100 dilution, staining PDGFR alpha in formalin-fixed, paraffin-embedded human brain cerebellum tissue by Immunohistochemistry.
Datasheets and documents
References (4)
ab124392 has been referenced in 4 publications.
- Buffolo M et al. Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling. Cell Rep 29:270-282.e5 (2019). PubMed: 31597091
- Stammnitz MR et al. The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils. Cancer Cell 33:607-619.e15 (2018). IHC-P . PubMed: 29634948
- Steger CM et al. Gene therapy with antisense oligonucleotides silencing c-myc reduces neointima formation and vessel wall thickness in a mouse model of vein graft disease. Exp Mol Pathol 105:1-9 (2018). IHC-P ; Mouse . PubMed: 29775572
- Duan M et al. Obovatol inhibits the growth and aggressiveness of tongue squamous cell carcinoma through regulation of the EGF-mediated JAK-STAT signaling pathway. Mol Med Rep 18:1651-1659 (2018). PubMed: 29845251
