Overview

  • Product name

    Anti-PDGFR alpha antibody [RM0004-3G28]
    See all PDGFR alpha primary antibodies
  • Description

    Rat monoclonal [RM0004-3G28] to PDGFR alpha
  • Host species

    Rat
  • Specificity

    Does not bind to PDGF receptor beta
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse
  • Immunogen

    Recombinant fragment corresponding to Mouse PDGFR alpha (extracellular).

Properties

Applications

Our Abpromise guarantee covers the use of ab51875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
WB
  • Application notes
    IHC-P: 1/50 - 1/100. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. The recommended protease is proteinase K, 20 ug/ml in PBS for 10 - 20 minutes.
    WB: 1/400 - 1/800. Predicted molecular weight: 180 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
    • Tissue specificity

      Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.
    • Involvement in disease

      Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
    • Sequence similarities

      Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
      Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 protein kinase domain.
    • Cellular localization

      Membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • Alpha-type platelet-derived growth factor receptor antibody
      • CD140 antigen-like family member A antibody
      • CD140a antibody
      • CD140a antigen antibody
      • MGC74795 antibody
      • PDGF alpha chain antibody
      • PDGF Receptor alpha antibody
      • PDGF-R-alpha antibody
      • PDGFR 2 antibody
      • PDGFR alpha antibody
      • PDGFR2 antibody
      • PDGFRA antibody
      • PDGFRA/BCR fusion antibody
      • PGFRA_HUMAN antibody
      • Platelet derived growth factor receptor 2 antibody
      • Platelet derived growth factor receptor alpha antibody
      • Platelet derived growth factor receptor alpha polypeptide antibody
      • Platelet derived growth factor receptor antibody
      • Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein antibody
      • RHEPDGFRA antibody
      see all

    Images

    • ab51875 at 1/100 dilution, staining PDGF Receptor alpha in LPS exposed mouse pancreatic tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

    References

    This product has been referenced in:

    • Gao Z  et al. PDGFRa/PDGFRß signaling balance modulates progenitor cell differentiation into white and beige adipocytes. Development 145:N/A (2018). Read more (PubMed: 29158445) »
    • Daquinag AC  et al. Targeted Proapoptotic Peptides Depleting Adipose Stromal Cells Inhibit Tumor Growth. Mol Ther 24:34-40 (2016). Read more (PubMed: 26316391) »
    See all 3 Publications for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab51875.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

    Sign up