Overview

  • Product name

  • Description

    Goat polyclonal to PDIA2/PDIP
  • Host species

    Goat
  • Tested applications

    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human PDIA2/PDIP aa 340-351 (internal sequence).
    Sequence:

    C-NLETTKKYAPVD


    Database link: Q13087

  • Positive control

    • Human Heart and Human Small Intestine tissue. Human Pancreas lysate
  • General notes

     This product was previously labelled as PDIA2

     

Properties

Applications

Our Abpromise guarantee covers the use of ab110195 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 57 kDa.
ELISA 1/64000.
IHC-P Use a concentration of 3.75 µg/ml.

Target

  • Function

    Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.
  • Tissue specificity

    Highly expressed in pancreas (at protein level).
  • Sequence similarities

    Belongs to the protein disulfide isomerase family.
    Contains 2 thioredoxin domains.
  • Post-translational
    modifications

    The disulfide-linked homodimer exhibits an enhanced chaperone activity.
    Glycosylated.
  • Cellular localization

    Endoplasmic reticulum lumen.
  • Information by UniProt
  • Database links

  • Alternative names

    • Pancreas specific protein disulfide isomerase antibody
    • Pancreas-specific protein disulfide isomerase antibody
    • Pancreatic protein disulfide isomerase antibody
    • PDA2 antibody
    • PDI antibody
    • PDIA2 antibody
    • PDIA2_HUMAN antibody
    • PDIp antibody
    • PDIR antibody
    • Protein disulfide isomerase A2 antibody
    • Protein disulfide isomerase antibody
    • Protein disulfide isomerase associated 2 antibody
    • Protein disulfide isomerase family A member 2 antibody
    • Protein disulfide isomerase pancreatic antibody
    • Protein disulfide-isomerase A2 antibody
    • Rho GDP dissociation inhibitor gamma antibody
    see all

Images

  • ab110195 at 3.75 µg/ml staining PDIA2/PDIP in Human Heart Formalin-Fixed, Paraffin-Embedded tissue.

  • ab110195 at 3.75 µg/ml staining PDIA2/PDIP in Human small intestine Formalin-Fixed, Paraffin-Embedded tissue.

  • Anti-PDIA2/PDIP antibody (ab110195) at 0.03 µg/ml + Human Pancreas lysate at 35 µg

    Developed using the ECL technique.

    Predicted band size: 57 kDa



    Primary incubation was 1 hour

References

This product has been referenced in:

  • Rawarak N  et al. Protein Disulfide Isomerase Inhibitor Suppresses Viral Replication and Production during Antibody-Dependent Enhancement of Dengue Virus Infection in Human Monocytic Cells. Viruses 11:N/A (2019). Read more (PubMed: 30781856) »
See 1 Publication for this product

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