Overview

  • Product name

  • Description

    Rabbit polyclonal to PDSS2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human PDSS2 (internal sequence). The exact sequence is proprietary.
    Database link: Q86YH6

  • Positive control

    • HeLa cell lysate; Human liver cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab200375 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB 1/500 - 1/2000. Predicted molecular weight: 44 kDa.

Target

  • Function

    Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.
  • Pathway

    Cofactor biosynthesis; ubiquinone biosynthesis.
  • Involvement in disease

    Defects in PDSS2 are a cause of coenzyme Q10 deficiency (COQ10D) [MIM:607426]. Coenzyme Q10 deficiency is an autosomal recessive disorder with variable manifestations. It can be associated with three main clinical phenotypes: a predominantly myopathic form with central nervous system involvement, an infantile encephalomyopathy with renal dysfunction and an ataxic form with cerebellar atrophy.
  • Sequence similarities

    Belongs to the FPP/GGPP synthase family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • All-trans-decaprenyl-diphosphate synthase subunit 2 antibody
    • bA59I9.3 antibody
    • C6orf210 antibody
    • Candidate tumor suppressor protein antibody
    • chromosome 6 open reading frame 210 antibody
    • Decaprenyl pyrophosphate synthase subunit 2 antibody
    • decaprenyl pyrophosphate synthetase subunit 2 antibody
    • Decaprenyl-diphosphate synthase subunit 2 antibody
    • DLP1 antibody
    • DLP1_HUMAN antibody
    • hDLP1 antibody
    • Pdss2 antibody
    • prenyl (decaprenyl) diphosphate synthase, subunit 2 antibody
    • subunit 2 of decaprenyl diphosphate synthase antibody
    see all

Images

  • Anti-PDSS2 antibody (ab200375) at 1/400 dilution + HeLa cell lysate at 40 µg

    Predicted band size: 44 kDa


    Exposure time: 20 seconds


    8% SDS-PAGE

  • Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling PDSS2 with ab200375 at 1/30 dilution.

References

ab200375 has not yet been referenced specifically in any publications.

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