PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (ab141406)

Overview

  • Product name

    PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant
  • Description

    Selective NF-κB inhibitor; antioxidant
  • Alternative names

    • Ammonium pyrrolidinedithiocarbamate
  • Biological description

    Selective NF-κB inhibitor. Inhibits translation of nitric oxide synthase mRNA to prevent induction. Metal ion chelator and antioxidant. Active in vitro.

  • CAS Number

    5108-96-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Eberhardt W  et al. Pyrrolidine dithiocarbamate differentially affects interleukin 1 beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells. Biochem Biophys Res Commun 200:163-70 (1994). Read more (PubMed: 7513157) »
  • Schini-Kerth V  et al. Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta. Eur J Pharmacol 265:83-7 (1994). Read more (PubMed: 7533726) »
  • Bessho R  et al. Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem Pharmacol 48:1883-9 (1994). Read more (PubMed: 7986199) »
See all 5 Publications for this product

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