Key features and details
- Rabbit polyclonal to PDZ-RhoGEF
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PDZ-RhoGEF antibody
See all PDZ-RhoGEF primary antibodies
DescriptionRabbit polyclonal to PDZ-RhoGEF
SpecificityThis antibody detects endogenous levels of total PDZ-RhoGEF protein.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide corresponding to Human PDZ-RhoGEF (N terminal).
- A549 and COLO cell extracts.
Previously labelled as ARHGEF11.
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine)
PBS without Mg2+ and Ca2+
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab110059 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Our Abpromise guarantee covers the use of ab110059 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 168 kDa.|
FunctionMay play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Tissue specificityUbiquitously expressed.
Sequence similaritiesContains 1 DH (DBL-homology) domain.
Contains 1 PDZ (DHR) domain.
Contains 1 PH domain.
Contains 1 RGSL (RGS-like) domain.
DomainThe poly-Pro region is essential for plasma membrane localization upon stimulation.
Cellular localizationCytoplasm. Membrane. Translocated to the membrane upon stimulation.
- Information by UniProt
- ARHGB_HUMAN antibody
- ARHGEF 11 antibody
- ARHGEF11 antibody
ab110059 has been referenced in 2 publications.
- Zhang W et al. Transgenerational Obesity and Alteration of ARHGEF11 in the Rat Liver Induced by Intrauterine Hyperglycemia. J Diabetes Res 2019:6320839 (2019). PubMed: 31612150
- Zhang W et al. ARHGEF11 affecting the placental insulin signaling pathway in fetal macrosomia of normal glucose tolerance pregnant women. Placenta 63:7-14 (2018). WB, IHC-P . PubMed: 29486856