Overview

  • Product name

  • Description

    Rabbit polyclonal to PDZD3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment corresponding to Human PDZD3 aa 42-291.
    Database link: Q86UT5

  • Positive control

    • WB: Mouse kidney and heart tissue lysate. IHC-P: Human skin and kidney tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.4
    Preservative: 0.03% Proclin
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Protein G purified
  • Purification notes

    Purity >95%
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab235412 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.
WB 1/500 - 1/1000. Predicted molecular weight: 61 kDa.

Target

  • Function

    Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions.
  • Tissue specificity

    Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin.
  • Sequence similarities

    Contains 4 PDZ (DHR) domains.
  • Cellular localization

    Cell membrane. Cytoplasm. Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells.
  • Information by UniProt
  • Database links

  • Alternative names

    • IKEPP antibody
    • Intestinal and kidney enriched PDZ protein antibody
    • Intestinal and kidney-enriched PDZ protein antibody
    • Na(+)/H(+) exchange regulatory cofactor NHE-RF4 antibody
    • Na/Pi cotransporter C terminal associated protein 2 antibody
    • Na/Pi cotransporter C-terminal-associated protein 2 antibody
    • NaPi-Cap2 antibody
    • Natrium-phosphate cotransporter IIa C-terminal-associated protein 2 antibody
    • NHERF-4 antibody
    • NHERF4 antibody
    • NHRF4_HUMAN antibody
    • PDZ domain containing 2 antibody
    • PDZ domain containing 3 antibody
    • PDZ domain containing protein 2 antibody
    • PDZ domain-containing protein 2 antibody
    • PDZ domain-containing protein 3 antibody
    • PDZD 3 antibody
    • Pdzd3 antibody
    • PDZK2 antibody
    • Protein DLNB27 antibody
    • Sodium-hydrogen exchanger regulatory factor 4 antibody
    see all

Images

  • Paraffin-embedded human skin tissue stained for PDZD3 using ab235412 at 1/100 dilution in immunohistochemical analysis.

  • All lanes : Anti-PDZD3 antibody (ab235412) at 1/500 dilution

    Lane 1 : Mouse kidney tissue lysate
    Lane 2 : Mouse heart tissue lysate

    Secondary
    All lanes : Goat polyclonal to rabbit IgG at 1/10000 dilution

    Predicted band size: 61 kDa

  • Paraffin-embedded human kidney tissue stained for PDZD3 using ab235412 at 1/100 dilution in immunohistochemical analysis.

References

ab235412 has not yet been referenced specifically in any publications.

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