Anti-PDZD7 antibody (ab169060)
- Datasheet
- References
- Protocols
Overview
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Product nameAnti-PDZD7 antibody
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DescriptionMouse polyclonal to PDZD7
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Host speciesMouse
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Tested applicationsSuitable for: WBmore details
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Species reactivityReacts with: Human
Predicted to work with: Orangutan
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Immunogen
Full length protein, corresponding to amino acids 1-511 of Human PDZD7 (AAH29054.1).
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Positive control
- PDZD7 transfected 293T cell lysate.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
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Storage bufferpH: 7.20
Constituent: 99% PBS -
Concentration information loading... -
PurityProtein A purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab169060 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 55 kDa. |
Target
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Tissue specificityWeakly expressed in the inner ear. Expressed in the retinal pigment epithelium.
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Involvement in diseaseNote=A chromosomal aberration disrupting PDZD7 has been found in patients with non-syndromic sensorineural deafness. Translocation t(10;11),t(10;11).
Defects in PDZD7 are a cause of Usher syndrome type 2C (USH2C) [MIM:605472]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses. Note=PDZD7 mutations have been found in combination with mutations in USH2A and GPR98 in patients affected by Usher syndrome, suggesting a role as contributor to digenic Usher syndrome or a modifier of retinal disease expression. -
Sequence similaritiesContains 2 PDZ (DHR) domains.
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Cellular localizationCell projection > cilium. Nucleus.
- Information by UniProt
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Database links
- Entrez Gene: 79955 Human
- Omim: 612971 Human
- SwissProt: Q9H5P4 Human
- SwissProt: Q5RBI7 Orangutan
- Unigene: 438245 Human
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Alternative names
- 9130207N01 antibody
- EG435601 antibody
- OTTMUSP00000044304 antibody
see all
Images
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Western blot - Anti-PDZD7 antibody (ab169060)All lanes : Anti-PDZD7 antibody (ab169060) at 1 µg/ml
Lane 1 : PDZD7 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 15 µl per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
Developed using the ECL technique.
Predicted band size: 55 kDa
Datasheets and documents
Protocols
References
ab169060 has not yet been referenced specifically in any publications.
