Overview

  • Product name

  • Description

    Rabbit polyclonal to PDZK3/Pin1
  • Host species

    Rabbit
  • Specificity

    The antibody detects endogenous levels of total PDZK3/Pin1 protein.

  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to Human PDZK3/Pin1 (internal sequence).
    Database link: O15018

  • Positive control

    • Human prostate carcinoma tissue and HepG2 cells.
  • General notes

     This product was previously labelled as PDZK3

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.87% Sodium chloride

    PBS without Mg2+ and Ca2+
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab196631 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100.
ICC/IF 1/100 - 1/500.

Target

  • Relevance

    Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. PDZK3 contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, the PDZK3 gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.
  • Cellular localization

    Cytoplasmic, Endoplasmic reticulum, Nuclear and Secreted
  • Database links

  • Alternative names

    • Activated in prostate cancer protein antibody
    • AIPC antibody
    • KIAA0300 antibody
    • PAPIN antibody
    • PDZ domain containing 2 antibody
    • PDZ domain containing 3 antibody
    • PDZ domain containing protein 2 antibody
    • PDZ domain containing protein 3 antibody
    • PDZK 3 antibody
    • PIN1 antibody
    • Plakophilin related armadillo repeat protein interacting PDZ protein like antibody
    see all

Images

  • Immunofluorscence analysis of HepG2 cells labeling PDZK3/Pin1 with ab196631 at 1/100 dilution. The image on the right is treated with the synthesized peptide.

  • Immunohistochemical analysis of formalin fixed and paraffin embedded Human prostate carcinoma  tissue labeling PDZK3/Pin1 with ab196631 at 1/50 dilution. The image on the right is treated with the synthesized peptide.

References

This product has been referenced in:

See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab196631.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up