Key features and details
- Rabbit polyclonal to PDZK3/Pin1
- Suitable for: IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PDZK3/Pin1 antibody
See all PDZK3/Pin1 primary antibodies
DescriptionRabbit polyclonal to PDZK3/Pin1
The antibody detects endogenous levels of total PDZK3/Pin1 protein.
Tested applicationsSuitable for: IHC-P, ICC/IFmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Synthetic peptide corresponding to Human PDZK3/Pin1 (internal sequence).
Database link: O15018
- Human prostate carcinoma tissue and HepG2 cells.
This product was previously labelled as PDZK3
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
PBS without Mg2+ and Ca2+
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab196631 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/100.|
|ICC/IF||1/100 - 1/500.|
RelevanceProteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. PDZK3 contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, the PDZK3 gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.
Cellular localizationCytoplasmic, Endoplasmic reticulum, Nuclear and Secreted
- Activated in prostate cancer protein antibody
- AIPC antibody
- KIAA0300 antibody
Immunofluorscence analysis of HepG2 cells labeling PDZK3/Pin1 with ab196631 at 1/100 dilution. The image on the right is treated with the synthesized peptide.
Immunohistochemical analysis of formalin fixed and paraffin embedded Human prostate carcinoma tissue labeling PDZK3/Pin1 with ab196631 at 1/50 dilution. The image on the right is treated with the synthesized peptide.
ab196631 has been referenced in 1 publication.
- He F et al. miR-363 acts as a tumor suppressor in osteosarcoma cells by inhibiting PDZD2. Oncol Rep 41:2729-2738 (2019). PubMed: 30896877