Key features and details
- PE Rat monoclonal [MJ7/18] to CD105
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG2a
Product namePE Anti-CD105 antibody [MJ7/18]
See all CD105 primary antibodies
DescriptionPE Rat monoclonal [MJ7/18] to CD105
ConjugationPE. Ex: 488nm, Em: 575nm
Tested applicationsSuitable for: Flow Cytmore details
Species reactivityReacts with: Mouse
Tissue/ cell preparation: inflamed Mouse skin.
- Mouse brain derived endothelial (bEnd.3) cells and splenocytes
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.20
Preservative: 0.09% Sodium azide
Concentration information loading...
PurityProtein G purified
Light chain typekappa
Our Abpromise guarantee covers the use of ab93567 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Flow Cyt||Use 0.25-0.5µg for 105-8 cells.
ab134674 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
FunctionMajor glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
Tissue specificityEndoglin is restricted to endothelial cells in all tissues except bone marrow.
Involvement in diseaseDefects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
- Information by UniProt
- AI528660 antibody
- AI662476 antibody
- CD 105 antibody
ab93567 has been referenced in 7 publications.
- Lin S et al. Non-canonical NOTCH3 signalling limits tumour angiogenesis. Nat Commun 8:16074 (2017). PubMed: 28719575
- Yamamoto M et al. Osteogenic Potential of Mouse Adipose-Derived Stem Cells Sorted for CD90 and CD105 In Vitro. Stem Cells Int 2014:576358 (2014). Flow Cyt ; Mouse . PubMed: 25302065
- Wen ST et al. Amniotic fluid stem cells from EGFP transgenic mice attenuate hyperoxia-induced acute lung injury. PLoS One 8:e75383 (2013). PubMed: 24040409
- Pérez-Gómez E et al. A role for endoglin as a suppressor of malignancy during mouse skin carcinogenesis. Cancer Res 67:10268-77 (2007). WB . PubMed: 17974968
- Korpanty G et al. Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res 13:323-30 (2007). IHC-Fr . PubMed: 17200371
- Onoe T et al. Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice. J Immunol 175:139-46 (2005). IHC-Fr . PubMed: 15972640
- Quintanilla M et al. Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis. Oncogene 22:5976-85 (2003). WB, IHC-Fr . PubMed: 12955076