Key features and details
- PE Mouse monoclonal [WM15] to CD13, prediluted
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG1
Product namePE Anti-CD13 antibody [WM15], prediluted
See all CD13 primary antibodies
DescriptionPE Mouse monoclonal [WM15] to CD13, prediluted
ConjugationPE. Ex: 488nm, Em: 575nm
Species reactivityReacts with: Human
Predicted to work with: Non human primates
Human AML cells
The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions.
Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 0.2% BSA, PBS
Concentration information loading...
- Biotin Anti-CD13 antibody [WM15] (ab130430)
- PerCP/Cy5.5® Anti-CD13 antibody [WM15] (ab157316)
- Alexa Fluor® 488 Anti-CD13 antibody [WM15] (ab239271)
- APC Anti-CD13 antibody [WM15] (ab239295)
- PE/DyLight™ 594 Anti-CD13 antibody [WM15] (ab239330)
- Anti-CD13 antibody [WM15] - BSA and Azide free (ab252261)
- FITC Anti-CD13 antibody [WM15] (ab52461)
- Anti-CD13 antibody [WM15] (ab7417)
FunctionBroad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
Tissue specificityExpressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
Sequence similaritiesBelongs to the peptidase M1 family.
DomainAmino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies).
N- and O-glycosylated.
May undergo proteolysis and give rise to a soluble form.
Cellular localizationCell membrane. Cytoplasm > cytosol. A soluble form has also been detected.
- Information by UniProt
- Alanyl (membrane) aminopeptidase antibody
- Alanyl aminopeptidase antibody
- Aminopeptidase M antibody
ab69775 has been referenced in 5 publications.
- Kessler T et al. Aminopeptidase N (CD13): Expression, Prognostic Impact, and Use as Therapeutic Target for Tissue Factor Induced Tumor Vascular Infarction in Soft Tissue Sarcoma. Transl Oncol 11:1271-1282 (2018). PubMed: 30125801
- Schmidt LH et al. Potential therapeutic impact of CD13 expression in non-small cell lung cancer. PLoS One 12:e0177146 (2017). Flow Cyt ; Human . PubMed: 28604784
- Favaloro EJ et al. CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated. Exp Hematol 21:1695-701 (1993). PubMed: 7902291
- Bradstock KF et al. Human myeloid differentiation antigens identified by monoclonal antibodies: expression on leukemic cells. Pathology 17:392-9 (1985). PubMed: 3865147
- Bradstock KF et al. Myeloid progenitor surface antigen identified by monoclonal antibody. Br J Haematol 61:11-20 (1985). PubMed: 4052321