PE Anti-CD14 antibody [Tuk4] (ab186689)
Key features and details
- PE Mouse monoclonal [Tuk4] to CD14
- Suitable for: Flow Cyt
- Reacts with: Sheep, Rabbit, Goat, Cow, Cat, Dog, Human, Pig, Mink, Cynomolgus monkey, Llama
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG2a
Overview
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Product name
PE Anti-CD14 antibody [Tuk4]
See all CD14 primary antibodies -
Description
PE Mouse monoclonal [Tuk4] to CD14 -
Host species
Mouse -
Conjugation
PE. Ex: 488nm, Em: 575nm -
Tested applications
Suitable for: Flow Cytmore details -
Species reactivity
Reacts with: Sheep, Rabbit, Goat, Cow, Cat, Dog, Human, Pig, Mink, Cynomolgus monkey, Llama -
Immunogen
The details of the immunogen for this antibody are not available.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at 4°C (stable for up to 12 months). Store at +4°C. Do Not Freeze. Store In the Dark. -
Storage buffer
Preservative: 0.09% Sodium azide
Constituents: 93% PBS, 5% Sucrose, 1% BSA -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
Purified from Tissue culture supernatant. -
Clonality
Monoclonal -
Clone number
Tuk4 -
Isotype
IgG2a -
Research areas
Associated products
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab186689 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
Flow Cyt |
Use at an assay dependent concentration.
ab91363 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
Notes |
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Flow Cyt
Use at an assay dependent concentration. ab91363 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
Target
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Function
Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. -
Tissue specificity
Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. -
Sequence similarities
Contains 11 LRR (leucine-rich) repeats. -
Post-translational
modificationsN- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 929 Human
- Entrez Gene: 100037938 Pig
- Omim: 158120 Human
- SwissProt: Q95122 Cow
- SwissProt: P08571 Human
- Unigene: 163867 Human
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Alternative names
- CD 14 antibody
- CD_antigen=CD14 antibody
- CD14 antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab186689 has been referenced in 2 publications.
- Zhou L et al. Clinical improvement of sepsis by extracorporeal centrifugal leukocyte apheresis in a porcine model. J Transl Med 20:538 (2022). PubMed: 36419190
- Wang Y et al. Silence of TGF-ß1 gene expression reduces prrsv replication and potentiates immunity of immune cells of tibetan pig. Vet Anim Sci 8:100074 (2019). PubMed: 32734091