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    pe-cd1a-antibody-na134-ab22352.pdf

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Immunology Adaptive Immunity T Cells CD
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PE Anti-CD1a antibody [NA1/34] (ab22352)

  • Datasheet
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Key features and details

  • PE Mouse monoclonal [NA1/34] to CD1a
  • Reacts with: Human, Cynomolgus monkey
  • Conjugation: PE. Ex: 488nm, Em: 575nm
  • Isotype: IgG2a

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Overview

  • Product name

    PE Anti-CD1a antibody [NA1/34]
    See all CD1a primary antibodies
  • Description

    PE Mouse monoclonal [NA1/34] to CD1a
  • Host species

    Mouse
  • Conjugation

    PE. Ex: 488nm, Em: 575nm
  • Specificity

    ab222352 recognises specifically CD1a expressed by human cortical thymocytes, Langerhans cells, Dendritic cells and a subset of B cells.
  • Species reactivity

    Reacts with: Human, Cynomolgus monkey
  • Immunogen

    Tissue/ cell preparation (Human): Fresh human thymocytes

  • General notes

    Recommended negative control: Mouse IgG2a Negative Control

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    pH: 7.20
    Preservative: 0.09% Sodium azide
    Constituents: PBS, 1% BSA
  • Concentration information loading...
  • Purification notes

    Purified IgG prepared by ion exchange chromatography
  • Clonality

    Monoclonal
  • Clone number

    NA1/34
  • Myeloma

    NS1/1-Ag4-1
  • Isotype

    IgG2a
  • Research areas

    • Immunology
    • Adaptive Immunity
    • T Cells
    • CD

Associated products

  • Alternative Versions

    • Anti-CD1a antibody [NA1/34] (ab238463)
    • Anti-CD1a antibody [NA1/34] - BSA and Azide free (ab244579)
    • Alexa Fluor® 488 Anti-CD1a antibody [NA1/34] (ab256268)
  • Isotype control

    • PE Mouse IgG2a [X5563] - Isotype Control (ab91363)
  • Recombinant Protein

    • Recombinant Human CD1a protein (ab114359)

Applications

  • Application notes
    Flow Cyt: Use 10µl for 106 cells in 100µl.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
    • Tissue specificity

      Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.
    • Sequence similarities

      Contains 1 Ig-like (immunoglobulin-like) domain.
    • Cellular localization

      Cell membrane. Endosome membrane. Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts.
    • Target information above from: UniProt accession P06126 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 909 Human
      • Omim: 188370 Human
      • SwissProt: P06126 Human
      • Unigene: 1309 Human
      • Alternative names

        • CD 1a antibody
        • CD1 antibody
        • CD1a antibody
        • CD1A Antigen antibody
        • CD1A antigen, a polypeptide antibody
        • CD1a molecule antibody
        • CD1A_HUMAN antibody
        • cluster of differentiation 1 A antibody
        • cortical thymocyte antigen CD1A antibody
        • differentiation antigen CD1 alpha 3 antibody
        • epidermal dendritic cell marker CD1a antibody
        • FCB 6 antibody
        • FCB6 antibody
        • HTA 1 antibody
        • HTA1 antibody
        • hTa1 thymocyte antigen antibody
        • OTTHUMP00000018907 antibody
        • R 4 antibody
        • R4 antibody
        • T 6 antibody
        • T-cell surface antigen T6/Leu-6 antibody
        • T-cell surface glycoprotein CD1a antibody
        • T6 antibody
        see all

      Protocols

      • Flow cytometry protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (2)

      Publishing research using ab22352? Please let us know so that we can cite the reference in this datasheet.

      ab22352 has been referenced in 2 publications.

      • de Jong MA  et al. Mutz-3-derived Langerhans cells are a model to study HIV-1 transmission and potential inhibitors. J Leukoc Biol 87:637-43 (2010). PubMed: 20042470
      • de Jong MA  et al. Herpes simplex virus type 2 enhances HIV-1 susceptibility by affecting Langerhans cell function. J Immunol 185:1633-41 (2010). PubMed: 20592277

      Customer reviews and Q&As

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      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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