PE Anti-CD79b antibody [AT105-1] (ab33295)

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Key features and details

  • PE Mouse monoclonal [AT105-1] to CD79b
  • Reacts with: Human
  • Conjugation: PE. Ex: 488nm, Em: 575nm
  • Isotype: IgG1

Overview

  • Product name

    PE Anti-CD79b antibody [AT105-1]
    See all CD79b primary antibodies

  • Description

    PE Mouse monoclonal [AT105-1] to CD79b

  • Host species

    Mouse

  • Conjugation

    PE. Ex: 488nm, Em: 575nm

  • Specificity

    Recognises an extracellular region of human CD79b.

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Synthetic peptide corresponding to an extracellular region of human CD79 beta.

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid

  • Storage instructions

    Shipped at 4°C. Store at +4°C.

  • Storage buffer

    pH: 7.40
    Preservative: 0.09% Sodium azide
    Constituents: PBS, 1% BSA
  • Concentration information loading...

  • Purity

    Protein A purified

  • Clonality

    Monoclonal

  • Clone number

    AT105-1

  • Myeloma

    NS1

  • Isotype

    IgG1

  • Research areas

Associated products

Target

  • Function

    Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

  • Tissue specificity

    B-cells.

  • Involvement in disease

    Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

  • Sequence similarities

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    Contains 1 ITAM domain.

  • Post-translational
    modifications

    Phosphorylated on tyrosine upon B-cell activation.

  • Cellular localization

    Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
  • Information by UniProt

  • Database links

    • Alternative names

      • AGM6 antibody
      • B cell antigen receptor complex associated protein beta chain antibody
      • B cell specific glycoprotein B29 antibody
      • B-cell antigen receptor complex-associated protein beta chain antibody
      • B-cell-specific glycoprotein B29 antibody
      • B29 antibody
      • B29/Ig-beta/CD79b antibody
      • CD 79b antibody
      • CD79b antibody
      • CD79b antigen (immunoglobulin associated beta) antibody
      • CD79b antigen antibody
      • CD79b molecule antibody
      • CD79b molecule immunoglobulin associated beta antibody
      • CD79b protein antibody
      • CD79B_HUMAN antibody
      • Ig beta antibody
      • Ig-beta antibody
      • IGB antibody
      • Igbeta antibody
      • Immunoglobulin associated B29 antibody
      • Immunoglobulin associated B29 protein antibody
      • Immunoglobulin associated beta antibody
      • Immunoglobulin associated protein antibody
      • Immunoglobulin-associated B29 protein antibody
      • MGC108607 antibody
      see all

    References (0)

    Publishing research using ab33295? Please let us know so that we can cite the reference in this datasheet.

    ab33295 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Question

    I would like to know the standard PE:mAb ratio for your anti-CD79b antibodies. Catalog numbers are ab33295 and ab25578. Rough concentration of the antibody in the prep would be helpful as well.

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    Answer

    Thank you for your enquiry. Further to correspondence with the source of this antibody I can tell you that ab33295; The concentration of the most recent batch of ab33295 is 0.07mg/ml. Unfortunately we do not know the degree of labelling for this antibody. ab25578; The concentration of this antibody is 0.1mg/mL. However, there is a degree of variation from lot to lot. As free PE is not removed from our conjugates, we would expect the PE:mab ratio to be around 1:1 or 2:1. I hope this information helps, please do not hesitate to contact us if you need any more advice or information.

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