Key features and details
- PE Armenian hamster monoclonal [Eat 2] to CD81
- Reacts with: Mouse, Rat
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG
Product namePE Anti-CD81 antibody [Eat 2]
See all CD81 primary antibodies
DescriptionPE Armenian hamster monoclonal [Eat 2] to CD81
Host speciesArmenian hamster
ConjugationPE. Ex: 488nm, Em: 575nm
Specificityab23553 recognises CD81, a 26kD cell surface glycoprotein that is also known as TAPA-1.
Species reactivityReacts with: Mouse, Rat
Tissue, cells or virus corresponding to Mouse CD81. Tissue/ cell preparation: 38C13, murine B cell line.
General notesMyeloma: Spleen cells from immunised Armenian hamsters were fused with cells of the mouse PX3-Ag.8.653 myeloma cell line.
Purified IgG conjugated to R. Phycoerythrin (RPE).
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.40
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA
Concentration information loading...
PurityProtein G purified
Clone numberEat 2
Use 10µl for 106 cells in 100µl.
Note: ab23553 induces homotypic aggregation of B cells and inhibits anti Ig and IL4 induced proliferation. ab23553 requires the presence of both extracellular loops of TAPA1 for binding.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionMay play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the viral receptor for HCV.
Tissue specificityHematolymphoid, neuroectodermal and mesenchymal tumor cell lines.
Involvement in diseaseDefects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
Sequence similaritiesBelongs to the tetraspanin (TM4SF) family.
- Information by UniProt
- 26 kDa cell surface protein TAPA 1 antibody
- 26 kDa cell surface protein TAPA-1 antibody
- 26 kDa cell surface protein TAPA1 antibody
ab23553 has not yet been referenced specifically in any publications.