PE Anti-CD81 antibody [Eat 2] (ab23553)

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Key features and details

  • PE Armenian hamster monoclonal [Eat 2] to CD81
  • Reacts with: Mouse, Rat
  • Conjugation: PE. Ex: 488nm, Em: 575nm
  • Isotype: IgG

Overview

  • Product name

    PE Anti-CD81 antibody [Eat 2]
    See all CD81 primary antibodies

  • Description

    PE Armenian hamster monoclonal [Eat 2] to CD81

  • Host species

    Armenian hamster

  • Conjugation

    PE. Ex: 488nm, Em: 575nm

  • Specificity

    ab23553 recognises CD81, a 26kD cell surface glycoprotein that is also known as TAPA-1.

  • Species reactivity

    Reacts with: Mouse, Rat

  • Immunogen

    Tissue, cells or virus corresponding to Mouse CD81. Tissue/ cell preparation: 38C13, murine B cell line.

  • General notes

    Myeloma: Spleen cells from immunised Armenian hamsters were fused with cells of the mouse PX3-Ag.8.653 myeloma cell line.

    Purified IgG conjugated to R. Phycoerythrin (RPE).

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Properties

Applications

  • Application notes
    Flow Cyt: 1/neat.
    Use 10µl for 106 cells in 100µl.

    Note: ab23553 induces homotypic aggregation of B cells and inhibits anti Ig and IL4 induced proliferation. ab23553 requires the presence of both extracellular loops of TAPA1 for binding.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • Function

      May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the viral receptor for HCV.

    • Tissue specificity

      Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.

    • Involvement in disease

      Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.

    • Sequence similarities

      Belongs to the tetraspanin (TM4SF) family.

    • Post-translational
      modifications

      Not glycosylated.

    • Cellular localization

      Membrane.
    • Information by UniProt

    • Database links

      • Alternative names

        • 26 kDa cell surface protein TAPA 1 antibody
        • 26 kDa cell surface protein TAPA-1 antibody
        • 26 kDa cell surface protein TAPA1 antibody
        • CD 81 antibody
        • CD81 antibody
        • CD81 antigen (target of antiproliferative antibody 1) antibody
        • CD81 antigen antibody
        • CD81 molecule antibody
        • CD81_HUMAN antibody
        • CVID6 antibody
        • S5.7 antibody
        • TAPA 1 antibody
        • TAPA1 antibody
        • Target of the antiproliferative antibody 1 antibody
        • Tetraspanin 28 antibody
        • Tetraspanin-28 antibody
        • Tetraspanin28 antibody
        • Tspan 28 antibody
        • Tspan-28 antibody
        • Tspan28 antibody
        see all

      References (0)

      Publishing research using ab23553? Please let us know so that we can cite the reference in this datasheet.

      ab23553 has not yet been referenced specifically in any publications.

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