Key features and details
- PE Mouse monoclonal [MEM-136] to HLA DR + HLA DP
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG1
Product namePE Anti-HLA DR + HLA DP antibody [MEM-136]
See all HLA DR + HLA DP primary antibodies
DescriptionPE Mouse monoclonal [MEM-136] to HLA DR + HLA DP
ConjugationPE. Ex: 488nm, Em: 575nm
Specificityab77134 recognizes a common epitope on the beta chain of human HLA-DR and HLA-DP. It reacts with alpha/beta dimer as well as with dissociated beta subunit.
Species reactivityReacts with: Human
Tissue/ cell preparation (Human); PHA-activated peripheral blood lymphocytes.
- human blood cells
Conjugates are made from highly purified antibodies (>95% by SDS-PAGE).
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 0.2% BSA, 0.2% PBS
0.2% BSA (high-grade protease free)
Concentration information loading...
Purification notesThe protein A/G purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is then purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceHuman MHC class II antigens are transmembrane glycoproteins composed of an alpha (36 kDa) and a beta chain (27kDa) and are expressed primarily on antigen presenting cells. Human MHC class II genes are located in the HLA-D region that encodes at least 6 alpha and 10 beta chain genes. Three loci, DR, DQ and DP, encode the major products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells and therefore have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.
Cellular localizationCell Membrane; Single pass type I membrane protein
- HLA DP antibody
- HLA DR antibody
- MHC Class II antibody
ab77134 has not yet been referenced specifically in any publications.