PE Anti-Integrin alpha 4+beta 7 antibody [DATK32] (ab95788)
![Flow Cytometry - PE Anti-Integrin alpha 4+beta 7 antibody [DATK32] (ab95788)](https://www.abcam.com/ps/products/95/ab95788/Images/Integrin-alpha-4beta-7-Primary-antibodies-ab95788-1.gif "Flow Cytometry - PE Anti-Integrin alpha 4+beta 7 antibody [DATK32] (ab95788)")
Key features and details
- PE Rat monoclonal [DATK32] to Integrin alpha 4+beta 7
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG2a
Overview
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Product name
PE Anti-Integrin alpha 4+beta 7 antibody [DATK32]
See all Integrin alpha 4+beta 7 primary antibodies -
Description
PE Rat monoclonal [DATK32] to Integrin alpha 4+beta 7 -
Host species
Rat -
Conjugation
PE. Ex: 488nm, Em: 575nm -
Tested applications
Suitable for: Flow Cytmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
TK1 cells.
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Positive control
- C57BL/6 splenocytes
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General notes
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.20
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
DATK32 -
Isotype
IgG2a -
Light chain type
kappa -
Research areas
Associated products
Applications
Our Abpromise guarantee covers the use of ab95788 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Flow Cyt | Use 1µg for 105 cells. A 100 µl volume is recommended for staining the cell sample.
ab134674 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
|
Target
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Relevance
Integrin alpha 4 beta 7, also known as, the lymphocyte Peyer's patch adhesion molecule (LPAM1) is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. -
Cellular localization
Membrane; Single pass type I membrane protein. -
Database links
- Entrez Gene: 16401 Mouse
- Entrez Gene: 16421 Mouse
- SwissProt: P26011 Mouse
- SwissProt: Q00651 Mouse
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Alternative names
- Antigen CD49D antibody
- CD49d antibody
- IA4 antibody
see all
Images
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Flow Cytometry - PE Anti-Integrin alpha 4+beta 7 antibody [DATK32] (ab95788)ab95788 at 0.5µg dilution staining Integrin alpha 4+beta 7 in C57BL/6 splenocytes by Flow Cytometry.
Datasheets and documents
References (2)
ab95788 has been referenced in 2 publications.
- Andrew DP et al. Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. J Immunol 153:3847-61 (1994). PubMed: 7523506
- Hamann A et al. Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol 152:3282-93 (1994). PubMed: 7511642
