PE Anti-KLRG1 antibody [2F1] (ab25205)
Key features and details
- PE Syrian hamster monoclonal [2F1] to KLRG1
- Reacts with: Mouse
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG
Related conjugates and formulations
Overview
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Product name
PE Anti-KLRG1 antibody [2F1]
See all KLRG1 primary antibodies -
Description
PE Syrian hamster monoclonal [2F1] to KLRG1 -
Host species
Syrian hamster -
Conjugation
PE. Ex: 488nm, Em: 575nm -
Species reactivity
Reacts with: Mouse -
Immunogen
Tissue, cells or virus corresponding to Mouse KLRG1.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. Do Not Freeze. Store undiluted. -
Storage buffer
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.14% Monobasic dihydrogen sodium phosphate, 0.87% Sodium chloride, 0.1% Gelatin -
Concentration information loading... -
Purity
Affinity purified -
Clonality
Monoclonal -
Clone number
2F1 -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Recombinant Protein
Target
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Function
Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. -
Tissue specificity
Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells. -
Sequence similarities
Contains 1 C-type lectin domain. -
Domain
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 50928 Mouse
- SwissProt: O88713 Mouse
- Unigene: 20434 Mouse
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Alternative names
- 2F1 Ag antibody
- 2F1 antibody
- C type lectin domain family 15 member A antibody
see all
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (8)
ab25205 has been referenced in 8 publications.
- Pauken KE et al. The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection. Cell Rep 31:107827 (2020). PubMed: 32610128
- Jennings RN et al. Type I interferon signaling enhances CD8+ T cell effector function and differentiation during murine gammaherpesvirus 68 infection. J Virol 88:14040-9 (2014). PubMed: 25253356
- Allie SR et al. Critical role for all-trans retinoic acid for optimal effector and effector memory CD8 T cell differentiation. J Immunol 190:2178-87 (2013). PubMed: 23338237
- Amoah S et al. High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion. J Immunol 190:5020-9 (2013). PubMed: 23589620
- Dong H et al. CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help. J Immunol 188:3829-38 (2012). Flow Cyt . PubMed: 22422886
- Amoah S et al. Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection. J Immunol 189:638-45 (2012). PubMed: 22706075
- Allie SR et al. Programmed death 1 regulates development of central memory CD8 T cells after acute viral infection. J Immunol 186:6280-6 (2011). Flow Cyt ; Mouse . PubMed: 21525385
- Blackburn SD et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 10:29-37 (2009). Flow Cyt ; Mouse . PubMed: 19043418
