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  1. Link

    pe-klrg1-antibody-2f1-ab25205.pdf

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Immunology Immunoglobulins Receptors
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PE Anti-KLRG1 antibody [2F1] (ab25205)

  • Datasheet
Submit a review Submit a question References (7)

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Abpromise

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Key features and details

  • PE Syrian hamster monoclonal [2F1] to KLRG1
  • Reacts with: Mouse
  • Conjugation: PE. Ex: 488nm, Em: 575nm
  • Isotype: IgG

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Recombinant Human KLRG1 protein (denatured) (ab139253)
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Overview

  • Product name

    PE Anti-KLRG1 antibody [2F1]
    See all KLRG1 primary antibodies
  • Description

    PE Syrian hamster monoclonal [2F1] to KLRG1
  • Host species

    Syrian hamster
  • Conjugation

    PE. Ex: 488nm, Em: 575nm
  • Species reactivity

    Reacts with: Mouse
  • Immunogen

    Tissue/ cell preparation (Mouse) - Activated NK (A-LAK) cells from B6 (H-2b) mice.

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C. Do Not Freeze. Store undiluted.
  • Storage buffer

    pH: 7.20
    Preservative: 0.09% Sodium azide
    Constituents: 0.14% Monobasic dihydrogen sodium phosphate, 0.87% Sodium chloride, 0.1% Gelatin
  • Concentration information loading...
  • Purity

    Affinity purified
  • Clonality

    Monoclonal
  • Clone number

    2F1
  • Isotype

    IgG
  • Research areas

    • Immunology
    • Immunoglobulins
    • Receptors

Associated products

  • Alternative Versions

    • violetFluor™ 450 Anti-KLRG1 antibody [2F1] (ab242067)
    • Anti-KLRG1 antibody [2F1] (ab25054)
  • Recombinant Protein

    • Recombinant Human KLRG1 protein (denatured) (ab139253)

Target

  • Function

    Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.
  • Tissue specificity

    Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells.
  • Sequence similarities

    Contains 1 C-type lectin domain.
  • Domain

    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D.
  • Cellular localization

    Cell membrane.
  • Target information above from: UniProt accession Q96E93 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 50928 Mouse
    • SwissProt: O88713 Mouse
    • Unigene: 20434 Mouse
    • Alternative names

      • 2F1 Ag antibody
      • 2F1 antibody
      • C type lectin domain family 15 member A antibody
      • C-type lectin domain family 15 member A antibody
      • CLEC15A antibody
      • ITIM containing receptor MAFA L antibody
      • ITIM-containing receptor MAFA-L antibody
      • Killer cell lectin like receptor G1 antibody
      • Killer cell lectin like receptor subfamily G member 1 antibody
      • Killer cell lectin-like receptor subfamily G member 1 antibody
      • KLRG 1 antibody
      • KLRG1 antibody
      • KLRG1 protein antibody
      • KLRG1_HUMAN antibody
      • MAFA 2F1 antibody
      • MAFA antibody
      • MAFA L antibody
      • MAFA like antibody
      • MAFA like receptor antibody
      • MAFA-like receptor antibody
      • MAFAL antibody
      • Mast cell function associated antigen (ITIM containing) antibody
      • Mast cell function associated antigen antibody
      • Mast cell function-associated antigen 2F1 antibody
      • Mast cell function-associated antigen antibody
      • Mast cell function-associated antigen, rat, homolog of antibody
      • MGC13600 antibody
      see all

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (7)

    Publishing research using ab25205? Please let us know so that we can cite the reference in this datasheet.

    ab25205 has been referenced in 7 publications.

    • Jennings RN  et al. Type I interferon signaling enhances CD8+ T cell effector function and differentiation during murine gammaherpesvirus 68 infection. J Virol 88:14040-9 (2014). PubMed: 25253356
    • Allie SR  et al. Critical role for all-trans retinoic acid for optimal effector and effector memory CD8 T cell differentiation. J Immunol 190:2178-87 (2013). PubMed: 23338237
    • Amoah S  et al. High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion. J Immunol 190:5020-9 (2013). PubMed: 23589620
    • Dong H  et al. CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help. J Immunol 188:3829-38 (2012). Flow Cyt . PubMed: 22422886
    • Amoah S  et al. Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection. J Immunol 189:638-45 (2012). PubMed: 22706075
    • Allie SR  et al. Programmed death 1 regulates development of central memory CD8 T cells after acute viral infection. J Immunol 186:6280-6 (2011). Flow Cyt ; Mouse . PubMed: 21525385
    • Blackburn SD  et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 10:29-37 (2009). Flow Cyt ; Mouse . PubMed: 19043418

    Customer reviews and Q&As

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