PE Anti-p75 NGF Receptor antibody [NGFR5], prediluted (ab157333)

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Key features and details

  • PE Mouse monoclonal [NGFR5] to p75 NGF Receptor, prediluted
  • Suitable for: Flow Cyt
  • Reacts with: Rabbit, Cat, Human, Ferret, Non human primates
  • Conjugation: PE. Ex: 488nm, Em: 575nm
  • Isotype: IgG1

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Carrier Free Unconjugated

Overview

  • Product name

    PE Anti-p75 NGF Receptor antibody [NGFR5], prediluted
    See all p75 NGF Receptor primary antibodies

  • Description

    PE Mouse monoclonal [NGFR5] to p75 NGF Receptor, prediluted

  • Host species

    Mouse

  • Conjugation

    PE. Ex: 488nm, Em: 575nm

  • Tested applications

    Suitable for: Flow Cytmore details

  • Species reactivity

    Reacts with: Rabbit, Cat, Human, Ferret, Non human primates
    Does not react with: Mouse, Rat

  • Immunogen

    Purified p75 NGF Receptor protein isolated from Human melanoma cell line A875.

  • Epitope

    The epitope is localized within amino acids 1-160.

  • Positive control

    • Human blood cells.

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab157333 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
Use at an assay dependent concentration.

(10ul per 100ul whole blood). ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
Notes
Flow Cyt
Use at an assay dependent concentration.

(10ul per 100ul whole blood). ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • Function

    Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.

  • Sequence similarities

    Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.

  • Domain

    Death domain is responsible for interaction with RANBP9.
    The extracellular domain is responsible for interaction with NTRK1.

  • Post-translational
    modifications

    N- and O-glycosylated.
    O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
    Phosphorylated on serine residues.

  • Cellular localization

    Membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • CD271 antibody
      • CD271 antigen antibody
      • Gp80 LNGFR antibody
      • Gp80-LNGFR antibody
      • Low affinity nerve growth factor receptor antibody
      • Low affinity neurotrophin receptor p75NTR antibody
      • Low-affinity nerve growth factor receptor antibody
      • Nerve growth factor receptor antibody
      • Nerve growth factor receptor TNFR superfamily member 16 antibody
      • NGF receptor antibody
      • Ngfr antibody
      • p75 ICD antibody
      • p75 Neurotrophin receptor antibody
      • p75 NTR antibody
      • p75(NTR) antibody
      • p75NTR antibody
      • TNFR Superfamily Member 16 antibody
      • TNFRSF16 antibody
      • TNR16_HUMAN antibody
      • Tumor necrosis factor receptor superfamily member 16 antibody
      see all

    References (1)

    Publishing research using ab157333? Please let us know so that we can cite the reference in this datasheet.

    ab157333 has been referenced in 1 publication.

    • Zhao F  et al. Programmed cell death 1 correlates with the occurrence and development of MG63 osteosarcoma. Oncol Lett 12:5199-5204 (2016). Flow Cyt ; Human . PubMed: 28105229

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