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  1. Link

    pe-p75-ngf-receptor-antibody-ngfr5-prediluted-ab157333.pdf

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Neuroscience Neurology process Growth and Development Neurotrophins
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PE Anti-p75 NGF Receptor antibody [NGFR5], prediluted (ab157333)

  • Datasheet
  • SDS
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Key features and details

  • PE Mouse monoclonal [NGFR5] to p75 NGF Receptor, prediluted
  • Reacts with: Rabbit, Cat, Human, Ferret, Non human primates
  • Conjugation: PE. Ex: 488nm, Em: 575nm
  • Isotype: IgG1

Overview

  • Product name

    PE Anti-p75 NGF Receptor antibody [NGFR5], prediluted
    See all p75 NGF Receptor primary antibodies
  • Description

    PE Mouse monoclonal [NGFR5] to p75 NGF Receptor, prediluted
  • Host species

    Mouse
  • Conjugation

    PE. Ex: 488nm, Em: 575nm
  • Species reactivity

    Reacts with: Rabbit, Cat, Human, Ferret, Non human primates
    Does not react with: Mouse, Rat
  • Immunogen

    Purified p75 NGF Receptor protein isolated from Human melanoma cell line A875.

  • Epitope

    The epitope is localized within amino acids 1-160.
  • Positive control

    • Human blood cells.
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    pH: 7.4
    Preservative: 0.1% Sodium azide
    Constituents: 0.2% BSA, 99% PBS
  • Concentration information loading...
  • Purity

    Size exclusion
  • Clonality

    Monoclonal
  • Clone number

    NGFR5
  • Isotype

    IgG1
  • Research areas

    • Neuroscience
    • Neurology process
    • Growth and Development
    • Neurotrophins
    • Stem Cells
    • Neural Stem Cells
    • Surface Molecules
    • Stem Cells
    • Mesenchymal Stem Cells
    • Surface Molecules

Associated products

  • Alternative Versions

    • APC Anti-p75 NGF Receptor antibody [NGFR5], prediluted (ab176522)
    • Anti-p75 NGF Receptor antibody [NGFR5] - BSA and Azide free (ab212682)
    • PE/Cy7® Anti-p75 NGF Receptor antibody [NGFR5] (ab234270)
    • PerCP/Cy5.5® Anti-p75 NGF Receptor antibody [NGFR5] (ab234446)
    • Anti-p75 NGF Receptor antibody [NGFR5] (ab3125)
  • Isotype control

    • PE Mouse IgG1 [B11/6] - Isotype Control (ab91357)

Target

  • Function

    Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
  • Sequence similarities

    Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • Domain

    Death domain is responsible for interaction with RANBP9.
    The extracellular domain is responsible for interaction with NTRK1.
  • Post-translational
    modifications

    N- and O-glycosylated.
    O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
    Phosphorylated on serine residues.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession P08138 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 101101519 Cat
    • Entrez Gene: 101680416 Ferret
    • Entrez Gene: 4804 Human
    • Entrez Gene: 100349095 Rabbit
    • Omim: 162010 Human
    • SwissProt: P08138 Human
    • Unigene: 415768 Human
    • Unigene: 681726 Human
    • Alternative names

      • CD271 antibody
      • CD271 antigen antibody
      • Gp80 LNGFR antibody
      • Gp80-LNGFR antibody
      • Low affinity nerve growth factor receptor antibody
      • Low affinity neurotrophin receptor p75NTR antibody
      • Low-affinity nerve growth factor receptor antibody
      • Nerve growth factor receptor antibody
      • Nerve growth factor receptor TNFR superfamily member 16 antibody
      • NGF receptor antibody
      • Ngfr antibody
      • p75 ICD antibody
      • p75 Neurotrophin receptor antibody
      • p75 NTR antibody
      • p75(NTR) antibody
      • p75NTR antibody
      • TNFR Superfamily Member 16 antibody
      • TNFRSF16 antibody
      • TNR16_HUMAN antibody
      • Tumor necrosis factor receptor superfamily member 16 antibody
      see all

    Protocols

    • Flow cytometry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (1)

    Publishing research using ab157333? Please let us know so that we can cite the reference in this datasheet.

    ab157333 has been referenced in 1 publication.

    • Zhao F  et al. Programmed cell death 1 correlates with the occurrence and development of MG63 osteosarcoma. Oncol Lett 12:5199-5204 (2016). Flow Cyt ; Human . PubMed: 28105229

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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