PE Anti-TCR alpha + TCR beta antibody [IP26] (ab99857)
Key features and details
- PE Mouse monoclonal [IP26] to TCR alpha + TCR beta
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG1
Overview
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Product name
PE Anti-TCR alpha + TCR beta antibody [IP26]
See all TCR alpha + TCR beta primary antibodies -
Description
PE Mouse monoclonal [IP26] to TCR alpha + TCR beta -
Host species
Mouse -
Conjugation
PE. Ex: 488nm, Em: 575nm -
Specificity
Recognizes a monomorphic determinant of TCR alpha/beta, the dominant subtype of T cell receptor expressed in human peripheral blood. -
Species reactivity
Reacts with: Human -
Immunogen
Human TCR alpha + TCR beta
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Positive control
- Human peripheral blood T cells
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General notes
Short term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. No reconstitution is necessary.
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 0.2% BSA, PBS -
Concentration information loading... -
Purity
Size exclusion -
Purification notes
The unconjugated antibody was purified by protein A (G) affinity chromatography (>95% by SDS-PAGE). After conjugation, the antibody was purified by size exclusion chromatography and adjusted for direct use. -
Clonality
Monoclonal -
Clone number
IP26 -
Isotype
IgG1 -
Research areas
Associated products
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Alternative Versions
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Isotype control
Target
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Relevance
The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55 kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunit has, external to the cell membrane, an N terminal variable domain and a C terminal constant domain. T cell receptors recognise foreign antigens which have been processed as small peptides and bound to major histocompatibility complex molecules at the surface of antigen presenting cells. Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. -
Cellular localization
Type I membrane protein. -
Database links
- Entrez Gene: 6955 Human
- Entrez Gene: 6957 Human
- Omim: 186880 Human
- Omim: 186930 Human
- SwissProt: P01848 Human
- SwissProt: P04435 Human
- Unigene: 494963 Human
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Alternative names
- FLJ22602 antibody
- MGC117436 antibody
- MGC22624 antibody
see all
References (1)
ab99857 has been referenced in 1 publication.
- Kuttruff S et al. NKp80 defines and stimulates a reactive subset of CD8 T cells. Blood 113:358-69 (2009). PubMed: 18922855
