PE Anti-TLR8 antibody [44C143] (ab45097)
Key features and details
- PE Mouse monoclonal [44C143] to TLR8
- Suitable for: Flow Cyt
- Reacts with: Mouse, Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG1
Overview
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Product name
PE Anti-TLR8 antibody [44C143]
See all TLR8 primary antibodies -
Description
PE Mouse monoclonal [44C143] to TLR8 -
Host species
Mouse -
Conjugation
PE. Ex: 488nm, Em: 575nm -
Tested applications
Suitable for: Flow Cytmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
This antibody was developed against a KLH-conjugated synthetic peptide of human TLR8, within amino acids 750-850.
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Positive control
- Ramos or RAW cells.
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General notes
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
44C143 -
Isotype
IgG1 -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab45097 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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Flow Cyt | Use 2-5µg for 106 cells. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
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Target
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Function
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. -
Tissue specificity
Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells. -
Sequence similarities
Belongs to the Toll-like receptor family.
Contains 23 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 TIR domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 51311 Human
- Entrez Gene: 170744 Mouse
- Omim: 300366 Human
- SwissProt: Q9NR97 Human
- SwissProt: P58682 Mouse
- Unigene: 660543 Human
- Unigene: 196676 Mouse
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Alternative names
- CD 288 antibody
- CD288 antibody
- CD288 antigen antibody
see all
Images
Datasheets and documents
References (5)
ab45097 has been referenced in 5 publications.
- Pritchard AL et al. Asthma is associated with multiple alterations in anti-viral innate signalling pathways. PLoS One 9:e106501 (2014). Flow Cyt ; Human . PubMed: 25203745
- Young BC et al. Longitudinal expression of Toll-like receptors on dendritic cells in uncomplicated pregnancy and postpartum. Am J Obstet Gynecol N/A:N/A (2013). Human . PubMed: 24291497
- Chong SZ et al. Human CD8? T cells drive Th1 responses through the differentiation of TNF/iNOS-producing dendritic cells. Eur J Immunol 41:1639-51 (2011). PubMed: 21469104
- Fahey LM et al. Reversal of human papillomavirus-specific T cell immune suppression through TLR agonist treatment of Langerhans cells exposed to human papillomavirus type 16. J Immunol 182:2919-28 (2009). Flow Cyt ; Human . PubMed: 19234187
- Levy O et al. Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. Blood 108:1284-90 (2006). PubMed: 16638933