Key features and details
- PE Mouse monoclonal [24-31] to TRAP/CD40L
- Suitable for: Flow Cyt
- Reacts with: Human, Cynomolgus monkey
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG1
Product namePE Anti-TRAP/CD40L antibody [24-31]
See all TRAP/CD40L primary antibodies
DescriptionPE Mouse monoclonal [24-31] to TRAP/CD40L
ConjugationPE. Ex: 488nm, Em: 575nm
Tested applicationsSuitable for: Flow Cytmore details
Species reactivityReacts with: Human, Cynomolgus monkey
Fusion protein corresponding to Human TRAP/CD40L.
- Human peripheral blood cells stimulated for 5 hours with Cell Stimulation Cocktail
Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.20
Preservative: 0.09% Sodium azide
Constituents: PBS, 0.2% BSA
Concentration information loading...
PurityProtein G purified
Light chain typekappa
- FITC Anti-TRAP/CD40L antibody [24-31] (ab134404)
- APC Anti-TRAP/CD40L antibody [24-31] (ab134406)
- Biotin Anti-TRAP/CD40L antibody [24-31] (ab134407)
- Anti-TRAP/CD40L antibody [24-31] - Low endotoxin, Azide free (ab234178)
- PE Anti-TRAP/CD40L antibody [24-31] (ab234220)
- FITC Anti-TRAP/CD40L antibody [24-31] (ab234271)
Our Abpromise guarantee covers the use of ab134405 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Flow Cyt||Use 5µl for 106 cells.|
FunctionMediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
Tissue specificitySpecifically expressed on activated CD4+ T-lymphocytes.
Involvement in diseaseDefects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
Sequence similaritiesBelongs to the tumor necrosis factor family.
modificationsThe soluble form derives from the membrane form by proteolytic processing.
N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.
Cellular localizationSecreted and Cell membrane.
- Information by UniProt
- CD 40L antibody
- CD154 antibody
- CD40 antigen ligand antibody
ab134405 has not yet been referenced specifically in any publications.