Pefloxacin mesylate, fluoroquinolone antibiotic agent (ab143284)

Overview

  • Product name

    Pefloxacin mesylate, fluoroquinolone antibiotic agent
  • Description

    Broad spectrum fluoroquinolone antibiotic agent
  • Biological description

    Broad spectrum fluoroquinolone antibiotic agent. Inhibits DNA gyrase, topoisomerase II and topoisomerase IV. Shows bactericidal effects against both Gram-positive and Gram-negative bacteria in vivo. Orally active. Blood-brain barrier permeable.
  • Purity

    > 99%
  • CAS Number

    70458-95-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-Ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid methanesulfonic acid
  • Molecular weight

    429.46
  • Molecular formula

    C17H20FN3O3.CH3SO3H
  • PubChem identifier

    119525
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=C(C=C2C(=C1)C(C(=CN2CC)C(=O)O)=O)N3CCN(CC3)C)F.S(C)(=O)(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Liu R  et al. Effects of systemic ornidazole, systemic and local compound ornidazole and pefloxacin mesylate on experimental periodontitis in rats. Med Sci Monit 18:BR95-102 (2012). Read more (PubMed: 22367122) »
  • Rotimi SO  et al. Tissue dyslipidemia in Salmonella-infected rats treated with amoxillin and pefloxacin. Lipids Health Dis 11:152 (2012). Read more (PubMed: 23137290) »
  • Kodaira H  et al. Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate. J Pharmacol Exp Ther 339:935-44 (2011). Read more (PubMed: 21934030) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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