• Product name
  • Description
    Mouse polyclonal to PEG10
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human), PEG10 (NP_001035242.1, 325 a.a)

  • Positive control
    • Human stomach tissue lysate, PEG10 transfected 293T cell lysate.



Our Abpromise guarantee covers the use of ab68780 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    WB: 1/500 - 1/1000. Detects bands of approximately 42 and 100 kDa (predicted molecular weight for isoform RF1: 37 kDa. predicted molecular weight for isoform RF1/RF2:80 kDa ).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.
    • Tissue specificity
      Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the HepG2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC).
    • Sequence similarities
      Contains 1 CCHC-type zinc finger.
    • Developmental stage
      Expressed in placenta during the first trimester of gestation (at protein level). In placenta, down-regulated at early hypoxic phase, and highly activated at 11-12 week of gestation.
    • Post-translational
      Isoform RF1/RF2 undergoes proteolytic cleavage.
    • Cellular localization
      Nucleus. Cytoplasm. Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the HepG2 cell line. Colocalized with ALK1.
    • Information by UniProt
    • Database links
    • Alternative names
      • AA407948 antibody
      • Edr antibody
      • Embryonal carcinoma differentiation regulated antibody
      • Embryonal carcinoma differentiation-regulated protein antibody
      • HB 1 antibody
      • HB1 antibody
      • KIAA1051 antibody
      • Mammalian retrotransposon-derived protein 2 antibody
      • Mar2 antibody
      • Mart2 antibody
      • MEF3 like 1 antibody
      • MEF3-like protein 1 antibody
      • MEF3L antibody
      • MEF3L1 antibody
      • MyEF 3 antibody
      • Myelin expression factor 3-like protein 1 antibody
      • Paternally expressed 10 antibody
      • Paternally expressed gene 10 ORF1 antibody
      • Paternally expressed gene 10 protein antibody
      • Peg10 antibody
      • PEG10 protein antibody
      • PEG10_HUMAN antibody
      • Putative uncharacterized protein PEG10 antibody
      • Retrotransposon gag domain containing 3 antibody
      • Retrotransposon gag domain-containing protein 3 antibody
      • Retrotransposon-derived gag-like polyprotein antibody
      • Retrotransposon-derived protein PEG10 antibody
      • RGAG3 antibody
      • Ty3/Gypsy-like protein antibody
      see all


    • Anti-PEG10 antibody (ab68780) at 1/500 dilution + Human stomach tissue lysate at 50 µg

      Goat Anti-Mouse IgG (H&L)-HRP Conjugate
      at 1/2500 dilution

      Predicted band size: 37 kDa
      Observed band size: 100 kDa (why is the actual band size different from the predicted?)

    • All lanes : Anti-PEG10 antibody (ab68780) at 1/500 dilution

      Lane 1 : PEG10 transfected 293T cell lysate
      Lane 2 : Non transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size: 37 kDa
      Observed band size: 42 kDa (why is the actual band size different from the predicted?)


    ab68780 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab68780.
    Please use the links above to contact us or submit feedback about this product.


    Sign up