Overview

  • Product name

    Peimine, Anti-inflammatory agent
  • Description

    Anti-inflammatory agent
  • Biological description

    Anti-inflammatory agent. MAPK inhibitor. Inhibits p38, ERK and JNK phosphorylation. Inhibits NFκB activation. Shows antitussive, expectorant and anti-inflammatory effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    23496-41-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3β,5α,6α,22β)-Cevane-3,6,20-triol
  • Molecular weight

    431.65
  • Molecular formula

    C27H45NO3
  • PubChem identifier

    131900
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(C6C5(CCC(C6)O)C)O)(C)O
  • Source

    Fritillaria sp.

  • Research areas

References

This product has been referenced in:

  • Chen LH  et al. Sex dependent pharmacokinetics, tissue distribution and excretion of peimine and peiminine in rats assessed by liquid chromatography-tandem mass spectrometry. J Ethnopharmacol 145:77-84 (2013). Read more (PubMed: 23123795) »
  • Yi PF  et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-?B and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol 35:567-72 (2013). Read more (PubMed: 23944357) »
  • Sun YG  et al. A comparative study on the pharmacokinetics of a traditional Chinese herbal preparation with the single herb extracts in rats by LC-MS/MS method. J Pharm Biomed Anal 81-82:34-43 (0). Read more (PubMed: 23624157) »

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