Anti-PELP1 antibody (ab84094)
Key features and details
- Rabbit polyclonal to PELP1
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-PELP1 antibody
See all PELP1 primary antibodies -
Description
Rabbit polyclonal to PELP1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Chimpanzee, Gorilla -
Immunogen
Synthetic peptide, corresponding to a region within the amino acids 1000-1050 of Human MNAR (accession number: AAN41255.1)
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Positive control
- Human breast adenocarcinoma. Mouse ovary tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab84094 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Notes |
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Likely to work with frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Function
Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. -
Tissue specificity
Isoform 2 is expressed in breast cancer cell lines. Isoform 1 is widely expressed. -
Domain
The Glu-rich region mediates histones interaction.
The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Nucleus. Cytoplasm. Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors. - Information by UniProt
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Database links
- Entrez Gene: 27043 Human
- Entrez Gene: 75273 Mouse
- Omim: 609455 Human
- SwissProt: Q8IZL8 Human
- SwissProt: Q9DBD5 Mouse
- Unigene: 513883 Human
- Unigene: 340601 Mouse
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Alternative names
- glutamic acid- and leucine-rich protein 1 antibody
- HMX3 antibody
- MNAR antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab84094 has been referenced in 1 publication.
- Janssen SF et al. Gene expression and functional annotation of the human ciliary body epithelia. PLoS One 7:e44973 (2012). IHC-FoFr ; Human . PubMed: 23028713