Key features and details
- Rabbit polyclonal to PEN2 - Carboxyterminal end
- Suitable for: WB, ICC/IF
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-PEN2 antibody - Carboxyterminal end
See all PEN2 primary antibodies
DescriptionRabbit polyclonal to PEN2 - Carboxyterminal end
Tested applicationsSuitable for: WB, ICC/IFmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide (Human) of 13 amino acids from near the C-terminus of PEN2
- K562 cells
Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferPreservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab62514 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 12 kDa (predicted molecular weight: 12 kDa).|
|ICC/IF||Use a concentration of 20 µg/ml.|
FunctionEssential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Tissue specificityWidely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
Sequence similaritiesBelongs to the PEN-2 family.
Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
- Information by UniProt
- Gamma secretase subunit PEN 2 antibody
- Gamma Secretase Subunit PEN2 antibody
- Gamma-secretase subunit PEN-2 antibody
Lane 1 : Anti-PEN2 antibody - Carboxyterminal end (ab62514) at 0.5 µg/ml
Lane 2 : Anti-PEN2 antibody - Carboxyterminal end (ab62514) at 1 µg/ml
Lane 3 : Anti-PEN2 antibody - Carboxyterminal end (ab62514) at 2 µg/ml
All lanes : K562 cell lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 12 kDa
Observed band size: 12 kDa
Immunofluorescence of K562 cells using ab62514 at 20 µg/ml.
ab62514 has been referenced in 2 publications.