Overview

  • Product name

    Penicillic acid, antibiotic mycotoxin
  • Description

    Mutagen. Antibiotic mycotoxin.
  • Biological description

    Mutagen. Antibiotic mycotoxin. Induces DNA single-strand breaks. Irreversible GDP-mannose dehydrogenase inhibitor. Inhibits RNA and protein synthesis (ED50 values are 180 and 600 μM respectively). Glutathione S-transferase inhibitor. Shows hepatotoxic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    90-65-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Bladt TT  et al. Bio-activity and dereplication-based discovery of ophiobolins and other fungal secondary metabolites targeting leukemia cells. Molecules 18:14629-50 (2013). Read more (PubMed: 24287995) »
  • Sorenson WG & Simpson J Toxicity of penicillic acid for rat alveolar macrophages in vitro. Environ Res 41:505-13 (1986). Read more (PubMed: 2430790) »
  • Dierickx PJ & De Beer JO Interaction of the mycotoxin penicillic acid with glutathione and rat liver glutathione S-transferases. Mycopathologia 86:137-41 (1984). Read more (PubMed: 6472435) »

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