Overview

  • Product name

    Pepstatin A, aspartic protease inhibitor
  • Description

    Potent selective aspartic protease inhibitor
  • Biological description

    Potent and selective aspartic protease inhibitor. Forms a 1:1 complex with pepsin, renin, cathepsins D and E. Inhibits solubilized γ-secretase and retroviral protease. Active in vivo.
  • Purity

    > 90%
  • CAS Number

    26305-03-3
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    685.89
  • Molecular formula

    C34H63N5O9
  • Sequence

    VVXAX (Modifications: N-terminal isovaleryl; X-3 = Sta; X-5 = Sta)
  • PubChem identifier

    5478883
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 1 mg/ml with heating
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)CC(C(CC(=O)O)O)NC(=O)C(C)NC(=O)CC(C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)CC(C)C)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Matúz K  et al. Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin. FEBS J 279:3276-86 (2012). Read more (PubMed: 22804908) »
  • Robinson PM  et al. Proteolytic processing of connective tissue growth factor in normal ocular tissues and during corneal wound healing. Invest Ophthalmol Vis Sci 53:8093-103 (2012). Read more (PubMed: 23139278) »
  • Matarrese P  et al. Pepstatin A alters host cell autophagic machinery and leads to a decrease in influenza A virus production. J Cell Physiol 226:3368-77 (2011). Read more (PubMed: 21344392) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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