PerCP Anti-CD11b antibody [DCIS1/18] (ab91145)
Key features and details
- PerCP Mouse monoclonal [DCIS1/18] to CD11b
- Reacts with: Human
- Conjugation: PerCP. Ex: 482nm, Em: 675nm
- Isotype: IgG2a
Overview
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Product name
PerCP Anti-CD11b antibody [DCIS1/18]
See all CD11b primary antibodies -
Description
PerCP Mouse monoclonal [DCIS1/18] to CD11b -
Host species
Mouse -
Conjugation
PerCP. Ex: 482nm, Em: 675nm -
Specificity
Integrin heterodimer of MW 165,95kD which comprises the receptor (CR3 am chain, CD11b/ CD18) for the complement component C3i. The CR3 receptor is expressed as a surface molecule by circulating monocytes and granulocytes and also by dendritic reticulum cells in sections of lympoid tissue. Expression is increased on activated granulocytes. -
Species reactivity
Reacts with: Human -
Immunogen
Tissue, cells or virus corresponding to Human CD11b. Immunogen: Dendritic cells derived from human monocytes.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2 -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Monoclonal -
Clone number
DCIS1/18 -
Isotype
IgG2a -
Research areas
Associated products
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Isotype control
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Recombinant Protein
Target
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Function
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. -
Tissue specificity
Predominantly expressed in monocytes and granulocytes. -
Involvement in disease
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. -
Sequence similarities
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
Domain
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3684 Human
- Omim: 120980 Human
- SwissProt: P11215 Human
- Unigene: 172631 Human
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Alternative names
- antigen CD11b (p170) antibody
- Antigen CD11b p170 antibody
- CD11 antigen like family member B antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (6)
ab91145 has been referenced in 6 publications.
- Salimi M et al. Activated innate lymphoid cell populations accumulate in human tumour tissues. BMC Cancer 18:341 (2018). Flow Cyt ; Human . PubMed: 29587679
- Pandya H et al. Differentiation of human and murine induced pluripotent stem cells to microglia-like cells. Nat Neurosci 20:753-759 (2017). PubMed: 28253233
- Salimi M et al. Cysteinyl leukotriene E4 activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D2 and epithelial cytokines. J Allergy Clin Immunol 140:1090-1100.e11 (2017). PubMed: 28115217
- Hams E et al. IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Proc Natl Acad Sci U S A 111:367-72 (2014). PubMed: 24344271
- Xue L et al. Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells. J Allergy Clin Immunol 133:1184-94 (2014). Flow Cyt ; Human . PubMed: 24388011
- Griffin DO & Rothstein TL A small CD11b+ human B1 cell subpopulation stimulates T cells and is expanded in lupus. J Exp Med 208:2591-8 (2011). WB ; Human . PubMed: 22110167