Key features and details
- PerCP Mouse monoclonal [A3-B1] to CD19
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: PerCP. Ex: 482nm, Em: 675nm
- Isotype: IgG2a
Product namePerCP Anti-CD19 antibody [A3-B1]
See all CD19 primary antibodies
DescriptionPerCP Mouse monoclonal [A3-B1] to CD19
ConjugationPerCP. Ex: 482nm, Em: 675nm
SpecificityThis antibody is B lineage specific and reacts with early B cell precursors, pre pre B cells, pre B cells, B cells, intermediate B cells, mature B cells and some plasmacytoid cells. Plasma cells were found to be negative. The antibody does not react with other haemopoïetic cells. The monoclonal antibody also reacts with pre B cell lines, B lymphoblastoid cell lines and Burkitt cell lines, and with 50% of myeloma cell lines. Virtually all non T ALL, B CLL and B cell lymphomas were found to be positive, myeloma cells were found to be negative.
Tested applicationsSuitable for: Flow Cytmore details
Species reactivityReacts with: Human
Tissue/ cell preparation (Human)
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.20
Preservative: 0.09% Sodium azide
Constituent: 1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab91157 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionAssembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Involvement in diseaseDefects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
Sequence similaritiesContains 2 Ig-like C2-type (immunoglobulin-like) domains.
modificationsPhosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.
- Information by UniProt
- Antibody deficiency due to defect in CD19 antibody
- Antibody deficiency due to defect in CD19, included antibody
- AW495831 antibody
ab91157 has not yet been referenced specifically in any publications.