PerCP Anti-CD4 antibody [MEM-241] (ab65951)
Key features and details
- PerCP Mouse monoclonal [MEM-241] to CD4
- Reacts with: Human, Cynomolgus monkey
- Conjugation: PerCP. Ex: 482nm, Em: 675nm
- Isotype: IgG1
Overview
-
Product name
PerCP Anti-CD4 antibody [MEM-241]
See all CD4 primary antibodies -
Description
PerCP Mouse monoclonal [MEM-241] to CD4 -
Host species
Mouse -
Conjugation
PerCP. Ex: 482nm, Em: 675nm -
Species reactivity
Reacts with: Human, Cynomolgus monkey -
Immunogen
Two N terminal domains of human CD4 fused to human IgG1 Fc
-
General notes
The purified antibody is conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
Preservative: 0.097% Sodium azide
Constituents: PBS, 0.2% BSA -
Concentration information loading... -
Purity
Size exclusion -
Purification notes
purity >95% by SDS-PAGE. -
Clonality
Monoclonal -
Clone number
MEM-241 -
Isotype
IgG1 -
Research areas
Associated products
-
Alternative Versions
- APC Anti-CD4 antibody [MEM-241] (ab18280)
- FITC Anti-CD4 antibody [MEM-241] (ab18281)
- PE Anti-CD4 antibody [MEM-241] (ab18282)
- APC/Cy7® Anti-CD4 antibody [MEM241] (ab233298)
- PE/Cy7® Anti-CD4 antibody [MEM241] (ab233660)
- Alexa Fluor® 700 Anti-CD4 antibody [MEM-241] (ab270671)
- Biotin Anti-CD4 antibody [MEM-241] (ab28069)
-
Isotype control
Target
-
Function
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. -
Sequence similarities
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Post-translational
modificationsPalmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. -
Cellular localization
Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. - Information by UniProt
-
Database links
- Entrez Gene: 101864991 Cynomolgus monkey
- Entrez Gene: 920 Human
- Omim: 186940 Human
- SwissProt: P79185 Cynomolgus monkey
- SwissProt: P01730 Human
- Unigene: 631659 Human
-
Alternative names
- CD 4 antibody
- CD4 (L3T4) antibody
- CD4 antibody
see all
Datasheets and documents
-
SDS download
-
Datasheet download
References (3)
ab65951 has been referenced in 3 publications.
- Chua KV et al. Octyl Gallate Induces Pancreatic Ductal Adenocarcinoma Cell Apoptosis and Suppresses Endothelial-Mesenchymal Transition-Promoted M2-Macrophages, HSP90a Secretion, and Tumor Growth. Cells 9:N/A (2019). PubMed: 31905895
- Xue L et al. Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells. J Allergy Clin Immunol 133:1184-94 (2014). Flow Cyt ; Human . PubMed: 24388011
- Bastien JP et al. Photodepletion differentially affects CD4+ Tregs versus CD4+ effector T cells from patients with chronic graft-versus-host disease. Blood 116:4859-69 (2010). Flow Cyt ; Human . PubMed: 20798236