Key features and details
- PerCP Mouse monoclonal [MEM-06] to CD41, prediluted
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: PerCP. Ex: 482nm, Em: 675nm
- Isotype: IgG1
Product namePerCP Anti-CD41 antibody [MEM-06], prediluted
See all CD41 primary antibodies
DescriptionPerCP Mouse monoclonal [MEM-06] to CD41, prediluted
ConjugationPerCP. Ex: 482nm, Em: 675nm
Tested applicationsSuitable for: Flow Cytmore details
Species reactivityReacts with: Human
Tissue, cells or virus corresponding to Human CD41. Leukocytes of patient suffering from LGL-type leukaemia.
Database link: P08514
- Flow Cyt: Human peripheral blood.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS, 0.5% BSA
Concentration information loading...
Purification notesab134373 is conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. Purity >95% by SDS-PAGE.
- PE Anti-CD41 antibody [MEM-06], prediluted (ab134372)
- FITC Anti-CD41 antibody [MEM-06] (ab21851)
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- PE/Cy5® Anti-CD41 antibody [MEM-06] (ab233450)
- PE/Cy7® Anti-CD41 antibody [MEM-06] (ab239313)
- Alexa Fluor® 700 Anti-CD41 antibody [MEM-06] (ab270670)
- Biotin Anti-CD41 antibody [MEM-06] (ab28065)
- APC Anti-CD41 antibody [MEM-06] (ab55866)
Our Abpromise guarantee covers the use of ab134373 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Flow Cyt||Use at an assay dependent concentration.
10 μl reagent / 100 μl of whole blood or 106 cells in a suspension.
FunctionIntegrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Tissue specificityIsoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
Involvement in diseaseDefects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
Sequence similaritiesBelongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
- Information by UniProt
- antigen CD41 antibody
- BDPLT16 antibody
- BDPLT2 antibody
ab134373 has been referenced in 1 publication.
- Nitulescu II et al. Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation. EBioMedicine 26:112-125 (2017). Flow Cyt ; Human . PubMed: 29239838