Key features and details
- PerCP Mouse monoclonal [P.seK02,22] to CD62P
- Reacts with: Human
- Conjugation: PerCP. Ex: 482nm, Em: 675nm
- Isotype: IgG2b
Product namePerCP Anti-CD62P antibody [P.seK02,22]
See all CD62P primary antibodies
DescriptionPerCP Mouse monoclonal [P.seK02,22] to CD62P
ConjugationPerCP. Ex: 482nm, Em: 675nm
Species reactivityReacts with: Human
Human platelet membrane glycoproteins.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.2
Preservative: 0.09% Sodium azide
Constituent: 1% BSA
Concentration information loading...
PurityImmunogen affinity purified
FunctionCa(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
Tissue specificityStored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
Involvement in diseaseDefects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Sequence similaritiesBelongs to the selectin/LECAM family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 9 Sushi (CCP/SCR) domains.
- Information by UniProt
- Antigen CD62 antibody
- CD62 antibody
- CD62 antigen-like family member P antibody
ab91132 has been referenced in 1 publication.
- Scopel-Guerra A et al. The Impact of Helicobacter pylori Urease upon Platelets and Consequent Contributions to Inflammation. Front Microbiol 8:2447 (2017). Flow Cyt . PubMed: 29312166