PerCP/Cy5.5® Anti-CD14 antibody [MEM-15], prediluted (ab157312)

Submit a review Submit a question References (3)

Key features and details

  • PerCP/Cy5.5® Mouse monoclonal [MEM-15] to CD14, prediluted
  • Reacts with: Human, Non human primates
  • Conjugation: PerCP/Cy5.5®. Ex: 482nm, Em: 690nm
  • Isotype: IgG1

Overview

  • Product name

    PerCP/Cy5.5® Anti-CD14 antibody [MEM-15], prediluted
    See all CD14 primary antibodies

  • Description

    PerCP/Cy5.5® Mouse monoclonal [MEM-15] to CD14, prediluted

  • Host species

    Mouse

  • Conjugation

    PerCP/Cy5.5®. Ex: 482nm, Em: 690nm

  • Species reactivity

    Reacts with: Human, Non human primates

  • Immunogen

    A crude mixture of Human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria.

  • Positive control

    • Human blood cells.

  • General notes

    Purified antibody is conjugated with tandem dye PerCP/Cy5.5® under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

Target

  • Function

    Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.

  • Tissue specificity

    Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

  • Sequence similarities

    Contains 11 LRR (leucine-rich) repeats.

  • Post-translational
    modifications

    N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

  • Cellular localization

    Cell membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • CD 14 antibody
      • CD_antigen=CD14 antibody
      • CD14 antibody
      • CD14 antigen antibody
      • CD14 molecule antibody
      • CD14_HUMAN antibody
      • LPS-R antibody
      • Mo2 antibody
      • Monocyte differentiation antigen CD14 antibody
      • Monocyte differentiation antigen CD14 urinary form antibody
      • Monocyte differentiation antigen CD14, membrane-bound form antibody
      • Myeloid cell specific leucine rich glycoprotein antibody
      • Myeloid cell-specific leucine-rich glycoprotein antibody
      see all

    References (3)

    Publishing research using ab157312? Please let us know so that we can cite the reference in this datasheet.

    ab157312 has been referenced in 3 publications.

    • Kozbial A  et al. Automated generation of immature dendritic cells in a single-use system. J Immunol Methods 457:53-65 (2018). PubMed: 29625078
    • Sing A  et al. Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression. J Exp Med 196:1017-24 (2002). PubMed: 12391013
    • Funda DP  et al. CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro: lipopolysaccharide activation of epithelial cells revisited. Infect Immun 69:3772-81 (2001). PubMed: 11349042

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    There are currently no Customer reviews or Questions for ab157312.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com