Overview

  • Product name

    Perifosine, Akt inhibitor
  • Description

    Akt inhibitor; alkylphospholipid
  • Biological description

    Alkylphospholipid and Akt inhibitor. Antiproliferative activity in vitro (IC50 = 0.6 - 8.9 μM). Anticancer activity in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    157716-52-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Hideshima T  et al. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood 107:4053-62 (2006). Read more (PubMed: 16418332) »
  • Kondapaka SB  et al. Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation. Mol Cancer Ther 2:1093-103 (2003). Read more (PubMed: 14617782) »
  • Patel V  et al. Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest. Cancer Res 62:1401-9 (2002). Read more (PubMed: 11888912) »

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