Overview

  • Product name
    Anti-Perilipin-1 antibody - N-terminal
    See all Perilipin-1 primary antibodies
  • Description
    Guinea pig polyclonal to Perilipin-1 - N-terminal
  • Host species
    Guinea pig
  • Specificity
    ab192716 reacts specifically with Perilipins (1 and 2) located at the surface of intracellular storage lipid droplets present e.g. in the adrenal gland, adipocytes of white and brown adipose tissue and cultured cells such as 3T3-L1 adipocytes and cultured steroidogenic adrenal cortical and Leydig cells. It also is a useful pathological marker, since Perilipin-1 becames expressed de novo in hepatocyte steatogenesis. ab192716 does not cross-react with ADRP (Adipophilin) or TIP47 proteins (additional members of the PAT-family).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Cow, Human
  • Immunogen

    Synthetic peptide corresponding to Human Perilipin-1 aa 1-20 (N terminal). (Duplicated N terminus of Perilipin-1, aa 1-20)
    Sequence:

    MAVNKGLTLLDGDLPEQENV


    Database link: O60240

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab192716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000. Predicted molecular weight: 56 kDa.

(ECL)

Target

  • Function
    Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness.
  • Tissue specificity
    Adipocytes.
  • Sequence similarities
    Belongs to the perilipin family.
  • Post-translational
    modifications
    Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet.
  • Cellular localization
    Lipid droplet. Lipid droplet surface-associated.
  • Information by UniProt
  • Database links
  • Alternative names
    • Lipid droplet associated protein antibody
    • Lipid droplet-associated protein antibody
    • PERI antibody
    • Perilipin A antibody
    • Perilipin antibody
    • Perilipin-1 antibody
    • PerilipinA antibody
    • PLIN antibody
    • PLIN1 antibody
    • PLIN1_HUMAN antibody
    see all

References

ab192716 has not yet been referenced specifically in any publications.

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