Perilipin-1 peptide (ab5009)

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Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5009 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Lyophilised

  • Additional notes

    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat perilipin-1, catalog ab3526. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • Reconstitution
    >95% pure, lyophilized synthetic peptide. Reconstitute with 0.1 ml of distilled water.

General Info

  • Alternative names

    • Lipid droplet associated protein
    • Lipid droplet-associated protein
    • PERI
    • Perilipin
    • Perilipin A
    • Perilipin-1
    • PerilipinA
    • PLIN
    • PLIN1
    • PLIN1_HUMAN
    see all

  • Function

    Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness.

  • Tissue specificity

    Adipocytes.

  • Sequence similarities

    Belongs to the perilipin family.

  • Post-translational
    modifications

    Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet.

  • Cellular localization

    Lipid droplet. Lipid droplet surface-associated.
  • Information by UniProt

References

This product has been referenced in:

  • Linden JR  et al. Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination. MBio 6:e02513 (2015). IHC-P, ICC, IHC - Wholemount ; Mouse . Read more (PubMed: 26081637) »
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