Perilipin-1 peptide (ab5009)

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Key features and details

  • Suitable for: Blocking

Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5009 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Lyophilized

  • Additional notes

    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat perilipin-1, catalog ab3526. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • Reconstitution
    >95% pure, lyophilized synthetic peptide. Reconstitute with 0.1 ml of distilled water.

General Info

  • Alternative names

    • Lipid droplet associated protein
    • Lipid droplet-associated protein
    • PERI
    • Perilipin
    • Perilipin A
    • Perilipin-1
    • PerilipinA
    • PLIN
    • PLIN1
    • PLIN1_HUMAN
    see all

  • Function

    Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness.

  • Tissue specificity

    Adipocytes.

  • Sequence similarities

    Belongs to the perilipin family.

  • Post-translational
    modifications

    Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet.

  • Cellular localization

    Lipid droplet. Lipid droplet surface-associated.
  • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (2)

Publishing research using ab5009? Please let us know so that we can cite the reference in this datasheet.

ab5009 has been referenced in 2 publications.

  • Seki M  et al. Periostin-expressing cell-specific transforming growth factor-ß inhibition in pulmonary artery prevents pulmonary arterial hypertension. PLoS One 14:e0220795 (2019). PubMed: 31437169
  • Linden JR  et al. Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination. MBio 6:e02513 (2015). IHC-P, ICC, IHC - Wholemount ; Mouse . PubMed: 26081637

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