Overview

  • Product name

    Anti-Peroxiredoxin 1/PAG antibody
    See all Peroxiredoxin 1/PAG primary antibodies
  • Description

    Goat polyclonal to Peroxiredoxin 1/PAG
  • Host species

    Goat
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Cynomolgus monkey, Chinese hamster
  • Immunogen

    Synthetic peptide corresponding to Human Peroxiredoxin 1/PAG aa 106-117 (internal sequence).
    Sequence:

    C-SDPKRTIAQDYG


    Database link: NP_859048.1

  • Positive control

    • IHC-P: placenta or thyroid tissue. WB: HepG2, HEK293 or A431 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab109766 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 23-24 kDa (predicted molecular weight: 22 kDa).
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • Function

    Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.
  • Sequence similarities

    Belongs to the ahpC/TSA family.
    Contains 1 thioredoxin domain.
  • Post-translational
    modifications

    Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.
  • Cellular localization

    Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links

  • Alternative names

    • Heme binding 23 kDa protein antibody
    • MSP23 antibody
    • Natural killer cell-enhancing factor A antibody
    • NKEF A antibody
    • NKEF-A antibody
    • NKEFA antibody
    • OSF3 antibody
    • Osteoblast specific factor 3 antibody
    • PAG antibody
    • Paga antibody
    • PAGB antibody
    • Peroxiredoxin 1 antibody
    • Peroxiredoxin-1 antibody
    • PRDX1 antibody
    • PRDX1_HUMAN antibody
    • Proliferation associated gene A antibody
    • Proliferation-associated gene protein antibody
    • PRX1 antibody
    • PrxI antibody
    • TDPX2 antibody
    • Thioredoxin peroxidase 2 antibody
    • Thioredoxin-dependent peroxide reductase 2 antibody
    see all

Images

  • Anti-Peroxiredoxin 1/PAG antibody (ab109766) at 0.01 µg/ml (incubation time: 1 hour) + HepG2 lysate in RIPA buffer at 35 µg

    Developed using the ECL technique.

    Predicted band size: 22 kDa

  • ab109766 at 2.5µg/ml staining Peroxiredoxin 1/PAG in formalin-fixed, paraffin-embedded Human placenta tissue.

  • ab109766 at 2.5µg/ml staining Peroxiredoxin 1/PAG in formalin-fixed, paraffin-embedded Human thyroid tissue.

References

ab109766 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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