Overview

  • Product name

    Anti-PEX7 antibody [EPR7715(2)(B)]
    See all PEX7 primary antibodies
  • Description

    Rabbit monoclonal [EPR7715(2)(B)] to PEX7
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human PEX7 aa 50-150. The exact sequence is proprietary.

  • Positive control

    • Human fetal heart lysate, Human fetal muscle lysate, MCF7 cell lysate
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Dissociation constant (KD)

    KD = 1.38 x 10 -10 M
    Learn more about KD
  • Storage buffer

    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR7715(2)(B)
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab133754 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function

      Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.
    • Tissue specificity

      Ubiquitous. Highest expression in pancreas, skeletal muscle and heart.
    • Involvement in disease

      Defects in PEX7 are the cause of peroxisome biogenesis disorder complementation group 11 (PBD-CG11) [MIM:614879]. PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum. The PBD group is genetically heterogeneous with at least 13 distinct genetic groups as concluded from complementation studies.
      Defects in PEX7 are the cause of rhizomelic chondrodysplasia punctata type 1 (RCDP1) [MIM:215100]. RCDP1 is characterized by rhizomelic shortening of femur and humerus, vertebral disorders, cataract, cutaneous lesions and severe mental retardation.
      Defects in PEX7 are the cause of peroxisome biogenesis disorder 9B (PBD9B) [MIM:614879]. A peroxisome biogenesis disorder with unusually mild clinical and biochemical manifestations. Affected individuals manifest a variable phenotype similar to, and in some cases indistinguishable from, classic Refsum disease. Variable features include ocular abnormalities, sensorimotor neuropathy, ichthyosis, deafness, chondrodysplasia punctata without rhizomelia or growth failure.
    • Sequence similarities

      Belongs to the WD repeat peroxin-7 family.
      Contains 6 WD repeats.
    • Cellular localization

      Peroxisome. Cytoplasm.
    • Information by UniProt
    • Database links

    • Alternative names

      • PBD9B antibody
      • PCDP1 antibody
      • Peroxin 7 antibody
      • Peroxin-7 antibody
      • Peroxisomal PTS2 receptor antibody
      • Peroxisomal targeting signal 2 receptor antibody
      • Peroxisome biogenesis factor 7 antibody
      • Peroxisome targeting signal 2 receptor antibody
      • PEX7 antibody
      • PEX7 protein antibody
      • PEX7_HUMAN antibody
      • PTS2 receptor antibody
      • PTS2R antibody
      • RCDP1 antibody
      • RD antibody
      see all

    Images

    • All lanes : Anti-PEX7 antibody [EPR7715(2)(B)] (ab133754) at 1/1000 dilution

      Lane 1 : Human fetal heart lysate
      Lane 2 : Human fetal muscle lysate
      Lane 3 : MCF7 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution

      Predicted band size: 36 kDa

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    ab133754 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab133754.
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