PF 356231, MMP-12 inhibitor (ab145237)
- Datasheet
- References
Overview
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Product name
PF 356231, MMP-12 inhibitor -
Description
Potent and selective non-chelating MMP-12 inhibitor -
Biological description
Potent and selective non-chelating MMP-12 inhibitor (IC50 = 14 nM). Inhibits other MMPs at higher concentrations. Inhibits cancer cell migration and invasion. -
Purity
> 98% -
CAS Number
766536-21-4 -
Chemical structure
Properties
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Chemical name
3-Phenyl-3-[[4-(4-pyridin-4-ylphenyl)thiophene-2-carbonyl]amino]propanoic acid -
Molecular weight
428.50 -
Molecular formula
C25H20N2O3S -
PubChem identifier
21145408 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C(C=C1)C(CC(=O)O)NC(=O)C2=CC(=CS2)C3=CC=C(C=C3)C4=CC=NC=C4 -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Chung IC et al. Matrix metalloproteinase 12 is induced by heterogeneous nuclear ribonucleoprotein K and promotes migration and invasion in nasopharyngeal carcinoma. BMC Cancer 14:348 (2014). Read more (PubMed: 24885469) »
- Williams H et al. MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis. Cardiovasc Res 87:137-46 (2010). Read more (PubMed: 20139113) »
- Garbacki N et al. Matrix metalloproteinase 12 silencing: a therapeutic approach to treat pathological lung tissue remodeling? Pulm Pharmacol Ther 22:267-78 (2009). Read more (PubMed: 19327406) »
