Overview

  • Product name

    PF 356231, MMP-12 inhibitor
  • Description

    Potent and selective non-chelating MMP-12 inhibitor
  • Biological description

    Potent and selective non-chelating MMP-12 inhibitor (IC50 = 14 nM). Inhibits other MMPs at higher concentrations. Inhibits cancer cell migration and invasion.
  • Purity

    > 98%
  • CAS Number

    766536-21-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Chung IC  et al. Matrix metalloproteinase 12 is induced by heterogeneous nuclear ribonucleoprotein K and promotes migration and invasion in nasopharyngeal carcinoma. BMC Cancer 14:348 (2014). Read more (PubMed: 24885469) »
  • Williams H  et al. MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis. Cardiovasc Res 87:137-46 (2010). Read more (PubMed: 20139113) »
  • Garbacki N  et al. Matrix metalloproteinase 12 silencing: a therapeutic approach to treat pathological lung tissue remodeling? Pulm Pharmacol Ther 22:267-78 (2009). Read more (PubMed: 19327406) »

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