Overview

  • Product name

    PF-562271, ATP-competitive, reversible FAK Inhibitor
  • Description

    Potent, selective ATP-competitive, reversible FAK Inhibitor
  • Biological description

    Potent, selective ATP-competitive, reversible FAK Inhibitor (IC50 values are 1.5, 13, 30, 47 and 58 nM for FAK, PYK2, CDK2, CDK2 and CDK1 respectively). Downregulates AKT/mTOR and CAS activity. Induces apoptosis. Shows antitumor effects in vivo. Orally active.
  • Purity

    > 95%
  • CAS Number

    717907-75-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Crompton BD  et al. High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. Cancer Res 73:2873-83 (2013). Read more (PubMed: 23536552) »
  • Wendt MK  et al. Transforming growth factor-ß-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression. Oncogene 29:6485-98 (2010). Read more (PubMed: 20802523) »
  • Wendt MK & Schiemann WP Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis. Breast Cancer Res 11:R68 (2009). Read more (PubMed: 19740433) »
See 1 Publication for this product

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