PF 670462, casein kinase 1epsilon (CK1epsilon) and CK1delta inhibitor (ab120985)

Overview

  • Product name

    PF 670462, casein kinase 1epsilon (CK1epsilon) and CK1delta inhibitor
  • Description

    Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor
  • Biological description

    Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM for CK1ε and CK1δ, respectively). Shows >300-fold selectivity over CK2 and selectivity over more than 40 other kinases. Alters circadian rhythms in vivo.

    Also available in simple stock solutions (ab146728) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity

    > 99%
  • CAS Number

    950912-80-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Sprouse J  et al. Chronic treatment with a selective inhibitor of casein kinase I delta/epsilon yields cumulative phase delays in circadian rhythms. Psychopharmacology (Berl) 210:569-76 (2010). Read more (PubMed: 20407760) »
  • Meng QJ  et al. Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc Natl Acad Sci U S A 107:15240-5 (2010). Read more (PubMed: 20696890) »
  • Badura L  et al. An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. J Pharmacol Exp Ther 322:730-8 (2007). Read more (PubMed: 17502429) »

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