Overview

  • Product name

    PF-8380, Autotaxin inhibitor
  • Description

    Potent, specific Autotaxin inhibitor.
  • Alternative names

    • 3,5-dichlorobenzyl4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate
    • Autotaxin Inhibitor III
  • Purity

    > 98%
  • General notes

    Protect from air and light.

    DMSO (~20 mg/ml).

  • CAS Number

    1144035-53-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3,5-dichlorobenzyl4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate 
  • Molecular weight

    478.33
  • Molecular formula

    C22H21Cl2N3O5
  • PubChem identifier

    25265312
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    ClC1=CC(COC(N2CCN(CCC(C(C=C3)=CC(O4)=C3NC4=O)=O)CC2)=O)=CC(Cl)=C1
  • Source

    Synthetic

References

This product has been referenced in:

  • Gierse J  et al. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. J Pharmacol Exp Ther 334:310-7 (2010). Read more (PubMed: 20392816) »

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