PFI-2, SETD7 histone lysine methyltransferase inhibitor (ab223601)

Overview

  • Product name

    PFI-2, SETD7 histone lysine methyltransferase inhibitor
  • Description

    Potent and selective SETD7 histone lysine methyltransferase inhibitor
  • Biological description

    A potent and selective SETD7 histone lysine methyltransferase inhibitor. Ki = 0.33 nM and IC50 = 2 nM against SETD7. It displays > 1000-fold selectivity against DNMT1 and many other methyltransferases. No activity against 134 ion channel, GPCR, and enzyme targets (<35% inhibition at 10 μM). PFI-2 potently inhibits SETD7 in MCF7 cells.

  • Purity

    > 98%
  • General notes

    Protect from air.

  • CAS Number

    1627676-59-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
  • Molecular weight

    499.52
  • Molecular formula

    C23H25F4N3O3S
  • PubChem identifier

    71300326
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store In the Dark.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CCN(C1)C(=O)[C@@H](CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC(=C4CNCCC4=C3)F
  • Source

    Synthetic

References

ab223601 has not yet been referenced specifically in any publications.

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