Anti-PGC1 alpha antibody (ab54481)

Rabbit polyclonal PGC1 alpha antibody. Validated in WB, ELISA, IHC, ICC/IF and tested in Mouse, Rat, Human, Zebrafish. Cited in 155 publication(s). Independently reviewed in 23 review(s).

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ab54481 has been referenced in 157 publications.

  • Fappi A  et al. Omega-3 multiple effects increasing glucocorticoid-induced muscle atrophy: autophagic, AMPK and UPS mechanisms. Physiol Rep 7:e13966 (2019). PubMed: 30648357
  • Chen C  et al. Fibroblast growth factor 21 inhibition aggravates cardiac dysfunction in diabetic cardiomyopathy by improving lipid accumulation. Exp Ther Med 15:75-84 (2018). PubMed: 29375676
  • Na RS  et al. Itraconazole attenuates hepatic gluconeogenesis and promotes glucose uptake by regulating AMPK pathway. Exp Ther Med 15:2165-2171 (2018). PubMed: 29434820
  • McMurphy T  et al. Implementation of environmental enrichment after middle age promotes healthy aging. Aging (Albany NY) 10:1698-1721 (2018). PubMed: 30036185
  • He T  et al. Fat deposition deficiency is critical for the high mortality of pre-weanling newborn piglets. J Anim Sci Biotechnol 9:66 (2018). PubMed: 30155244
  • Liu D  et al. AMPK/PGC1a activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. Free Radic Biol Med 129:59-72 (2018). PubMed: 30172748
  • Liu X  et al. Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration. EMBO Mol Med 10:N/A (2018). PubMed: 30389681
  • Wahl D  et al. Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Rep 25:2234-2243.e6 (2018). PubMed: 30463018
  • He Y  et al. The browning of white adipose tissue and body weight loss in primary hyperparathyroidism. EBioMedicine N/A:N/A (2018). PubMed: 30528454
  • Zhou J  et al. Liraglutide induces beige fat development and promotes mitochondrial function in diet induced obesity mice partially through AMPK-SIRT-1-PGC1-a cell signaling pathway. Endocrine N/A:N/A (2018). PubMed: 30535743
  • Choi JH  et al. Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice. Int J Mol Sci 20:N/A (2018). PubMed: 30577593
  • Vargas D  et al. Thermogenic capacity of human periaortic adipose tissue is transformed by body weight. PLoS One 13:e0194269 (2018). PubMed: 29554135
  • Singh R  et al. Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases. Diabetes Metab Syndr Obes 11:65-84 (2018). PubMed: 29618935
  • Yu G  et al. Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nat Med 24:39-49 (2018). PubMed: 29200204
  • Sato M  et al. Detachment from the primary site and suspension in ascites as the initial step in metabolic reprogramming and metastasis to the omentum in ovarian cancer. Oncol Lett 15:1357-1361 (2018). PubMed: 29399186
  • Jia Y  et al. Dapagliflozin Aggravates Renal Injury via Promoting Gluconeogenesis in db/db Mice. Cell Physiol Biochem 45:1747-1758 (2018). PubMed: 29495021
  • Kuang Y  et al. Oxaloacetate induces apoptosis in HepG2 cells via inhibition of glycolysis. Cancer Med 7:1416-1429 (2018). PubMed: 29533007
  • Ramesh S  et al. SIRT3 activator Honokiol attenuates ß-Amyloid by modulating amyloidogenic pathway. PLoS One 13:e0190350 (2018). PubMed: 29324783
  • Velazquez-Villegas LA  et al. TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue. Nat Commun 9:245 (2018). PubMed: 29339725
  • Kang M  et al. Improved systemic metabolism and adipocyte biology in miR-150 knockout mice. Metabolism N/A:N/A (2018). WB ; Mouse . PubMed: 29352962
  • Hardee JP  et al. Inflammatory signalling regulates eccentric contraction-induced protein synthesis in cachectic skeletal muscle. J Cachexia Sarcopenia Muscle 9:369-383 (2018). WB . PubMed: 29215198
  • Chen YT  et al. A combination of Lactobacillus mali APS1 and dieting improved the efficacy of obesity treatment via manipulating gut microbiome in mice. Sci Rep 8:6153 (2018). PubMed: 29670255
  • Krysciak K  et al. Adaptation of motor unit contractile properties in rat medial gastrocnemius to treadmill endurance training: Relationship to muscle mitochondrial biogenesis. PLoS One 13:e0195704 (2018). PubMed: 29672614
  • Bae JY  et al. Effects of detraining and retraining on muscle energy-sensing network and meteorin-like levels in obese mice. Lipids Health Dis 17:97 (2018). PubMed: 29703203
  • Stancic A  et al. A lesson from the oxidative metabolism of hibernator heart: Possible strategy for cardioprotection. Comp Biochem Physiol B Biochem Mol Biol 219-220:1-9 (2018). WB . PubMed: 29501789
  • Graber TG  et al. Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. Exp Gerontol 106:88-100 (2018). WB . PubMed: 29452288
  • Yamashita Y  et al. Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle. Sci Rep 8:7766 (2018). PubMed: 29773865
  • Bae JY Aerobic Exercise Increases Meteorin-Like Protein in Muscle and Adipose Tissue of Chronic High-Fat Diet-Induced Obese Mice. Biomed Res Int 2018:6283932 (2018). PubMed: 29854769
  • Karlsson L  et al. Constitutive PGC-1a Overexpression in Skeletal Muscle Does Not Improve Morphological Outcome in Mouse Models of Brain Irradiation or Cortical Stroke. Neuroscience 384:314-328 (2018). WB ; Mouse . PubMed: 29859976
  • Botteri G  et al. The BACE1 product sAPPß induces ER stress and inflammation and impairs insulin signaling. Metabolism 85:59-75 (2018). WB . PubMed: 29526536
  • Yu B  et al. PGC-1a Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ. Cell Stem Cell 23:193-209.e5 (2018). PubMed: 30017591
  • Wang JL  et al. Antifibrotic role of PGC-1a-siRNA against TGF-ß1-induced renal interstitial fibrosis. Exp Cell Res 370:160-167 (2018). PubMed: 29913155
  • Liu HW & Chang SJ Moderate Exercise Suppresses NF-?B Signaling and Activates the SIRT1-AMPK-PGC1a Axis to Attenuate Muscle Loss in Diabetic db/db Mice. Front Physiol 9:636 (2018). PubMed: 29896118
  • Wood J  et al. BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle. Metabolism 87:113-122 (2018). PubMed: 29935237
  • Hasan-Olive MM  et al. A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1a-SIRT3-UCP2 Axis. Neurochem Res N/A:N/A (2018). PubMed: 30027365
  • Scalzo RL  et al. Glucagon-like peptide-1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats. Physiol Rep 6:e13754 (2018). PubMed: 29984491
  • Gao W  et al. NEFA-induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis. J Cell Mol Med 22:3408-3422 (2018). PubMed: 29602237
  • Saha P  et al. Activation of cyclin D1 affects mitochondrial mass following traumatic brain injury. Neurobiol Dis 118:108-116 (2018). PubMed: 30010002
  • Padrão AI  et al. Exercise training protects against cancer-induced cardiac remodeling in an animal model of urothelial carcinoma. Arch Biochem Biophys 645:12-18 (2018). WB ; Rat . PubMed: 29548774
  • Oh S  et al. Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles. Sci Rep 7:12902 (2017). PubMed: 29018242
  • Xiao Y  et al. p38a MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure. Cell Death Dis 8:e3110 (2017). IHC-P ; Human . PubMed: 29022907
  • Yang X  et al. Zinc enhances the cellular energy supply to improve cell motility and restore impaired energetic metabolism in a toxic environment induced by OTA. Sci Rep 7:14669 (2017). WB . PubMed: 29116164
  • Yuan X  et al. Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes. Exp Biol Med (Maywood) 242:930-938 (2017). WB ; Mouse . PubMed: 28440735
  • Piao L  et al. Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis. J Am Heart Assoc 6:N/A (2017). PubMed: 28963101
  • Li SY  et al. Increasing the level of peroxisome proliferator-activated receptor ? coactivator-1a in podocytes results in collapsing glomerulopathy. JCI Insight 2:N/A (2017). PubMed: 28724797
  • Kim K  et al. RORa controls hepatic lipid homeostasis via negative regulation of PPAR? transcriptional network. Nat Commun 8:162 (2017). PubMed: 28757615
  • Zoladz JA  et al. Effect of temperature on fatty acid metabolism in skeletal muscle mitochondria of untrained and endurance-trained rats. PLoS One 12:e0189456 (2017). WB . PubMed: 29232696
  • Vargas D  et al. Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue. Int J Endocrinol 2017:2945012 (2017). PubMed: 29209367
  • Lin H  et al. Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia. Dis Model Mech 10:1343-1352 (2017). PubMed: 29125827
  • Lizcano F  et al. Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor. Stem Cells Int 2017:2767916 (2017). PubMed: 29158739
  • Chen Z  et al. Hyperoside alleviates adriamycin-induced podocyte injury via inhibiting mitochondrial fission. Oncotarget 8:88792-88803 (2017). PubMed: 29179476
  • Zhang L  et al. Skeletal Muscle-Specific Overexpression of PGC-1a Induces Fiber-Type Conversion through Enhanced Mitochondrial Respiration and Fatty Acid Oxidation in Mice and Pigs. Int J Biol Sci 13:1152-1162 (2017). PubMed: 29104506
  • Sourdon J  et al. Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism. Theranostics 7:2757-2774 (2017). PubMed: 28824714
  • Lou PH  et al. Alterations in fatty acid metabolism and sirtuin signaling characterize early type-2 diabetic hearts of fructose-fed rats. Physiol Rep 5:N/A (2017). PubMed: 28830979
  • Perks KL  et al. Adult-onset obesity is triggered by impaired mitochondrial gene expression. Sci Adv 3:e1700677 (2017). PubMed: 28835921
  • Miura S  et al. Mitochondrial-Targeted Antioxidant Maintains Blood Flow, Mitochondrial Function, and Redox Balance in Old Mice Following Prolonged Limb Ischemia. Int J Mol Sci 18:N/A (2017). PubMed: 28869535
  • Meng XH  et al. Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes. Int J Biol Sci 13:985-995 (2017). PubMed: 28924380
  • Paré MF & Jasmin BJ Chronic 5-Aminoimidazole-4-Carboxamide-1-ß-d-Ribofuranoside Treatment Induces Phenotypic Changes in Skeletal Muscle, but Does Not Improve Disease Outcomes in the R6/2 Mouse Model of Huntington's Disease. Front Neurol 8:516 (2017). PubMed: 29021780
  • Ishimoto Y  et al. Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease. Mol Cell Biol N/A:N/A (2017). PubMed: 28993480
  • Liao CY  et al. Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins. Cell Discov 3:17039 (2017). PubMed: 29736257
  • Xing F  et al. The Anti-Warburg Effect Elicited by the cAMP-PGC1a Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes. Cell Rep 18:468-481 (2017). PubMed: 28076790
  • Bertholet AM  et al. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab 25:811-822.e4 (2017). PubMed: 28380374
  • Fan W  et al. PPARd Promotes Running Endurance by Preserving Glucose. Cell Metab 25:1186-1193.e4 (2017). PubMed: 28467934
  • Guo X  et al. DOCK2 deficiency mitigates HFD-induced obesity by reducing adipose tissue inflammation and increasing energy expenditure. J Lipid Res 58:1777-1784 (2017). PubMed: 28716822
  • Popov DV  et al. AMPK does not play a requisite role in regulation of PPARGC1A gene expression via the alternative promoter in endurance-trained human skeletal muscle. Exp Physiol 102:366-375 (2017). PubMed: 28074493
  • Le NH  et al. Absence of 4-1BB reduces obesity-induced atrophic response in skeletal muscle. J Inflamm (Lond) 14:9 (2017). WB ; Mouse . PubMed: 28503098
  • Kodo K  et al. Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice. PLoS One 12:e0173661 (2017). WB ; Mouse . PubMed: 28288167
  • Ran G  et al. Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio). PLoS One 12:e0180865 (2017). Zebrafish . PubMed: 28686680
  • Milton-Laskibar I  et al. Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment of Hepatic Steatosis in Rats. Nutrients 9:N/A (2017). WB ; Rat . PubMed: 28696376
  • Wang J  et al. Qiliqiangxin Enhances Cardiac Glucose Metabolism and Improves Diastolic Function in Spontaneously Hypertensive Rats. Evid Based Complement Alternat Med 2017:3197320 (2017). WB ; Rat . PubMed: 28706558
  • Yan F  et al. Mulberry Anthocyanin Extract Ameliorates Oxidative Damage in HepG2 Cells and Prolongs the Lifespan of Caenorhabditis elegans through MAPK and Nrf2 Pathways. Oxid Med Cell Longev 2017:7956158 (2017). WB . PubMed: 28713491
  • De Jong A  et al. Diaphragmatic function is enhanced in fatty and diabetic fatty rats. PLoS One 12:e0174043 (2017). PubMed: 28328996
  • Khani M  et al. Effect of thyme extract supplementation on lipid peroxidation, antioxidant capacity, PGC-1a content and endurance exercise performance in rats. J Int Soc Sports Nutr 14:11 (2017). WB . PubMed: 28439212
  • Suliman HB  et al. Mitochondrial quality-control dysregulation in conditional HO-1(-/-) mice. JCI Insight 2:e89676 (2017). PubMed: 28194437
  • Feng HZ & Jin JP Carbonic Anhydrase III Is Expressed in Mouse Skeletal Muscles Independent of Fiber Type-Specific Myofilament Protein Isoforms and Plays a Role in Fatigue Resistance. Front Physiol 7:597 (2016). WB . PubMed: 28018233
  • Shintaku J  et al. MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-?B. Cell Rep 17:514-526 (2016). PubMed: 27705798
  • Guan Y  et al. Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1a-SIRT3 signaling pathway. Int J Mol Med 37:1229-38 (2016). WB . PubMed: 27049825
  • Kannan A  et al. Mitochondrial Reprogramming Regulates Breast Cancer Progression. Clin Cancer Res 22:3348-60 (2016). PubMed: 26888829
  • Feng HZ  et al. Slow recovery of the impaired fatigue resistance in postunloading mouse soleus muscle corresponding to decreased mitochondrial function and a compensatory increase in type I slow fibers. Am J Physiol Cell Physiol 310:C27-40 (2016). PubMed: 26447205
  • Chen M  et al. Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-ß-boswellic acid in combination on isoproterenol-induced myocardial injury in rats. Int J Mol Med 37:1501-10 (2016). IHC . PubMed: 27121241
  • Zhang C  et al. The Engrailed-1 Gene Stimulates Brown Adipogenesis. Stem Cells Int 2016:7369491 (2016). WB . PubMed: 27148369
  • Camarda R  et al. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med 22:427-32 (2016). WB . PubMed: 26950360
  • Audet-Walsh É  et al. The PGC-1a/ERRa Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer. Cell Rep 14:920-931 (2016). PubMed: 26804918
  • Liu Z  et al. Mark4 promotes oxidative stress and inflammation via binding to PPAR? and activating NF-?B pathway in mice adipocytes. Sci Rep 6:21382 (2016). WB ; Mouse . PubMed: 26888669
  • Helman A  et al. p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion. Nat Med N/A:N/A (2016). WB . PubMed: 26950362
  • Rodriguez S  et al. Loss of CTRP1 disrupts glucose and lipid homeostasis. Am J Physiol Endocrinol Metab 311:E678-E697 (2016). PubMed: 27555298
  • Fernández-Torrón R  et al. Cancer risk in DM1 is sex-related and linked to miRNA-200/141 downregulation. Neurology 87:1250-7 (2016). PubMed: 27558368
  • Golko-Perez S  et al. A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1(G93A) ALS Mice. Neurotox Res N/A:N/A (2016). PubMed: 27826939
  • Zhou Y  et al. MicroRNA-29a induces insulin resistance by targeting PPARd in skeletal muscle cells. Int J Mol Med 37:931-8 (2016). WB ; Rat . PubMed: 26936652
  • Li L  et al. Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1a Pathway in Rats. Sci Rep 6:30272 (2016). PubMed: 27453548
  • Kim J  et al. Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1a. PLoS One 11:e0159990 (2016). WB ; Mouse . PubMed: 27454177
  • Handa P  et al. Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice. Am J Physiol Gastrointest Liver Physiol 310:G117-27 (2016). PubMed: 26564716
  • Buondonno I  et al. Mitochondria-Targeted Doxorubicin: A New Therapeutic Strategy against Doxorubicin-Resistant Osteosarcoma. Mol Cancer Ther 15:2640-2652 (2016). PubMed: 27466354
  • Yuan Y  et al. Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1a pathway. Clin Sci (Lond) 130:2181-2198 (2016). PubMed: 27613156
  • Huang YH  et al. Postnatal High-Fat Diet Increases Liver Steatosis and Apoptosis Threatened by Prenatal Dexamethasone through the Oxidative Effect. Int J Mol Sci 17:369 (2016). WB ; Rat . PubMed: 26978357
  • Basisty N  et al. Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: 'reverse' antagonistic pleiotropy? Aging Cell 15:634-45 (2016). WB ; Mouse, Human . PubMed: 27061426
  • Kong Q  et al. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med 38:1715-1726 (2016). WB ; Mouse . PubMed: 27840945
  • Martin JS  et al. Impact of external pneumatic compression target inflation pressure on transcriptome-wide RNA expression in skeletal muscle. Physiol Rep 4:N/A (2016). IHC-Fr ; Human . PubMed: 27884954
  • Dölle C  et al. Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease. Nat Commun 7:13548 (2016). IHC-P ; Human . PubMed: 27874000
  • Tran MT  et al. PGC1a drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature 531:528-32 (2016). PubMed: 26982719
  • Zou T  et al. Moderately decreased maternal dietary energy intake during pregnancy reduces fetal skeletal muscle mitochondrial biogenesis in the pigs. Genes Nutr 11:19 (2016). PubMed: 27551320
  • Albadawi H  et al. Revascularization and muscle adaptation to limb demand ischemia in diet-induced obese mice. J Surg Res 205:49-58 (2016). PubMed: 27620999
  • Doan KV  et al. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nat Commun 7:12733 (2016). PubMed: 27681312
  • Sun R  et al. Comparative molecular analysis of early and late cancer cachexia-induced muscle wasting in mouse models. Oncol Rep 36:3291-3302 (2016). PubMed: 27748895
  • Collier JB  et al. Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor ? Coactivator-1a by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions. J Biol Chem 291:26850-26859 (2016). PubMed: 27875304
  • Vargas D  et al. Regulation of human subcutaneous adipocyte differentiation by EID1. J Mol Endocrinol 56:113-22 (2016). PubMed: 26643909
  • Cavalera M  et al. Rose hip supplementation increases energy expenditure and induces browning of white adipose tissue. Nutr Metab (Lond) 13:91 (2016). PubMed: 27980600
  • Sun R  et al. Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBPß-regulated atrogin1 expression in cancer cachexia. Am J Physiol Cell Physiol 311:C101-15 (2016). PubMed: 27122162
  • Wang Z  et al. Effect of Allopurinol on Myocardial Energy Metabolism in Chronic Heart Failure Rats After Myocardial Infarct. Int Heart J 57:753-759 (2016). PubMed: 27818481
  • Lauritzen KH  et al. Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. Am J Physiol Heart Circ Physiol 309:H434-49 (2015). PubMed: 26055793
  • Gao X  et al. Insufficient glucose supply is linked to hypothermia upon cold exposure in high-fat diet-fed mice lacking PEMT. J Lipid Res 56:1701-10 (2015). PubMed: 26113536
  • Jankovic A  et al. Two key temporally distinguishable molecular and cellular components of white adipose tissue browning during cold acclimation. J Physiol 593:3267-80 (2015). IHC-P ; Rat . PubMed: 26096127
  • Philp LK  et al. Dietary enrichment with fish oil prevents high fat-induced metabolic dysfunction in skeletal muscle in mice. PLoS One 10:e0117494 (2015). WB ; Mouse . PubMed: 25658742
  • Lu Y  et al. Beneficial effects of astragaloside IV against angiotensin II-induced mitochondrial dysfunction in rat vascular smooth muscle cells. Int J Mol Med 36:1223-32 (2015). WB ; Rat . PubMed: 26398547
  • Cui XB  et al. RGC32 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice. J Endocrinol 224:127-37 (2015). WB ; Mouse . PubMed: 25385871
  • Kang HM  et al. Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development. Nat Med 21:37-46 (2015). PubMed: 25419705
  • Tsai S  et al. Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity. J Clin Invest 125:2952-64 (2015). PubMed: 26121750
  • Negrette-Guzmán M  et al. Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism. Evid Based Complement Alternat Med 2015:917435 (2015). PubMed: 26345660
  • Wang S  et al. G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor ? (PPAR?): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY. J Biol Chem 290:19544-57 (2015). PubMed: 26105050
  • Vargas D  et al. Modifications of Human Subcutaneous ADMSC after PPAR? Activation and Cold Exposition. Stem Cells Int 2015:196348 (2015). WB . PubMed: 26339249
  • Viale A  et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature : (2014). PubMed: 25119024
  • Warren BE  et al. Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat. Am J Physiol Endocrinol Metab 306:E658-67 (2014). PubMed: 24425766
  • Fahrenbach JP  et al. Abcc9 is required for the transition to oxidative metabolism in the newborn heart. FASEB J 28:2804-15 (2014). PubMed: 24648545
  • Guo P  et al. Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro. Toxicol Sci : (2014). IF . PubMed: 25159133
  • Ashmore T  et al. Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart. J Physiol 592:4715-31 (2014). WB . PubMed: 25172947
  • Yang CS  et al. The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy. Autophagy 10:785-802 (2014). PubMed: 24598403
  • Bruno NE  et al. Creb coactivators direct anabolic responses and enhance performance of skeletal muscle. EMBO J 33:1027-43 (2014). PubMed: 24674967
  • Tabony AM  et al. Protein phosphatase 2C-alpha knockdown reduces angiotensin II-mediated skeletal muscle wasting via restoration of mitochondrial recycling and function. Skelet Muscle 4:20 (2014). PubMed: 25625009
  • Velickovic K  et al. Expression and subcellular localization of estrogen receptors a and ß in human fetal brown adipose tissue. J Clin Endocrinol Metab 99:151-9 (2014). PubMed: 24217905
  • LaBarge S  et al. Estrogen-related receptor-a (ERRa) deficiency in skeletal muscle impairs regeneration in response to injury. FASEB J 28:1082-97 (2014). PubMed: 24277576
  • Dyle MC  et al. Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy. J Biol Chem 289:14913-24 (2014). PubMed: 24719321
  • Chen M  et al. Impaired glucose metabolism in response to high fat diet in female mice conceived by in vitro fertilization (IVF) or ovarian stimulation alone. PLoS One 9:e113155 (2014). WB ; Mouse . PubMed: 25405530
  • Crooks DR  et al. Elevated FGF21 secretion, PGC-1a and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle. Hum Mol Genet 23:24-39 (2014). Human . PubMed: 23943793
  • Marine A  et al. Peroxynitrite induced mitochondrial biogenesis following MnSOD knockdown in normal rat kidney (NRK) cells. Redox Biol 2:348-57 (2014). WB . PubMed: 24563852
  • Rivalin R  et al. The NFL-TBS.40-63 anti-glioblastoma peptide disrupts microtubule and mitochondrial networks in the T98G glioma cell line. PLoS One 9:e98473 (2014). WB ; Mouse, Human . PubMed: 24896268
  • Huang Z  et al. The stem cell factor/Kit signalling pathway regulates mitochondrial function and energy expenditure. Nat Commun 5:4282 (2014). PubMed: 24999927
  • Grahammer F  et al. mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A 111:E2817-26 (2014). PubMed: 24958889
  • Yao W  et al. Endoplasmic reticulum stress links hepatitis C virus RNA replication to wild-type PGC-1a/liver-specific PGC-1a upregulation. J Virol 88:8361-74 (2014). PubMed: 24829353
  • Chou CF  et al. KSRP ablation enhances brown fat gene program in white adipose tissue through reduced miR-150 expression. Diabetes 63:2949-61 (2014). PubMed: 24722250
  • Gabrielson M  et al. Expression of Mitochondrial Regulators PGC1a and TFAM as Putative Markers of Subtype and Chemoresistance in Epithelial Ovarian Carcinoma. PLoS One 9:e107109 (2014). WB ; Human . PubMed: 25243473
  • Pooya S  et al. The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nat Commun 5:4993 (2014). PubMed: 25256100
  • Missios P  et al. Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice. Nat Commun 5:4924 (2014). WB ; Mouse . PubMed: 25233189
  • Kumarasamy S  et al. Construction of two novel reciprocal conplastic rat strains and characterization of cardiac mitochondria. Am J Physiol Heart Circ Physiol 304:H22-32 (2013). WB ; Rat . PubMed: 23125210
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