Anti-PGEA1 antibody (ab230304)

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Overview

  • Product name

    Anti-PGEA1 antibody

  • Description

    Rabbit polyclonal to PGEA1

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WB, IHC-Pmore details

  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Cow

  • Immunogen

    Recombinant full length protein corresponding to Human PGEA1 aa 1-126.
    Sequence:

    MPFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQ SLKFENGQWIAETGVSGGVDRREVQRLRRRNQQLEEENNLLRLKVDILLD MLSESTAESHLMEKELDELRISRKRK


    Database link: Q9Y3M2

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • WB: Mouse lung lysate. IHC-P: Human heart tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab230304 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Detects a band of approximately 14 kDa (predicted molecular weight: 14 kDa).
IHC-P 1/20 - 1/200.

Target

  • Function

    Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.

  • Tissue specificity

    Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.

  • Sequence similarities

    Belongs to the chibby family.

  • Cellular localization

    Nucleus speckle. Golgi apparatus, trans-Golgi network. Nuclear, in a punctate manner. Also found in the trans-Golgi.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • ARPP-binding protein antibody
    • C22orf2 antibody
    • CBY antibody
    • Cby1 antibody
    • CBY1_HUMAN antibody
    • Cytosolic leucine rich protein antibody
    • Cytosolic leucine-rich protein antibody
    • Golgi and endoplasmic reticulum-associated 1 antibody
    • HRIHFB2025 antibody
    • PIGEA 14 antibody
    • PIGEA-14 antibody
    • PKD2 interactor antibody
    • PKD2 interactor, Golgi and endoplasmic reticulum-associated 1 antibody
    • Protein Chibby antibody
    • Protein chibby homolog 1 antibody
    see all

Images

  • Western blot - Anti-PGEA1 antibody (ab230304)
    Western blot - Anti-PGEA1 antibody (ab230304)
    Anti-PGEA1 antibody (ab230304) at 1/1000 dilution + Mouse lung lysate

    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution

    Predicted band size: 14 kDa
    Observed band size: 14 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGEA1 antibody (ab230304)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGEA1 antibody (ab230304)

    Paraffin-embedded human heart tissue stained for PGEA1 using ab230304 at 1/100 dilution in immunohistochemical analysis.

References

ab230304 has not yet been referenced specifically in any publications.

Publishing research using ab230304? Please let us know so that we can cite the reference in this datasheet.

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