Overview

  • Product name

  • Description

    Rabbit polyclonal to PGM1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human PGM1 aa 1-562.
    Database link: P36871

  • Positive control

    • WB: U-251 MG, U937, Jurkat and HeLa whole cell lysates. IHC-P: Human liver cancer and testis tissue. ICC/IF: HepG2 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab237523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/50 - 1/200.
WB 1/500 - 1/2000. Predicted molecular weight: 61 kDa.
IHC-P 1/20 - 1/200.

Target

  • Function

    This enzyme participates in both the breakdown and synthesis of glucose.
  • Involvement in disease

    Defects in PGM1 are the cause of glycogen storage disease type 14 (GSD14) [MIM:612934]. A metabolic disorder resulting in a myopathy characterized by exercise-induced intolerance with episodes of rhabdomyolysis, normal elevation of lactate, and hyperammonemia on a forearm-exercise test.
  • Sequence similarities

    Belongs to the phosphohexose mutase family.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • CDG1T antibody
    • Glucose phosphomutase 1 antibody
    • GSD14 antibody
    • OTTHUMP00000010519 antibody
    • OTTHUMP00000010520 antibody
    • PGM 1 antibody
    • PGM1 antibody
    • PGM1_HUMAN antibody
    • Phosphoglucomutase 1 antibody
    • Phosphoglucomutase-1 antibody
    • Phosphoglucomutase1 antibody
    see all

Images

  • All lanes : Anti-PGM1 antibody (ab237523) at 1/500 dilution

    Lane 1 : U-251 MG (Human brain glioma cell line) whole cell lysate
    Lane 2 : U937 (Human histiocytic lymphoma cell line) whole cell lysate
    Lane 3 : Jurkat (Human T cell leukemia cell line from peripheral blood) whole cell lysate
    Lane 4 : HeLa (Human epithelial cell line from cervix adenocarcinoma) whole cell lysate

    Secondary
    All lanes : Goat polyclonal to rabbit IgG at 1/10000 dilution

    Predicted band size: 61 kDa

  • Paraffin-embedded human liver cancer tissue stained for PGM1 using ab237523 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human testis tissue stained for PGM1 using ab237523 at 1/100 dilution in immunohistochemical analysis.

  • HepG2 (Human liver hepatocellular carcinoma cell line) cells stained for PGM1 (green) using ab237523 at 1/100 dilution in ICC/IF. Secondary antibody is an Alexa-Fluor® 488-conjugated Goat Anti-Rabbit IgG (H+L).

References

ab237523 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab237523.
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