Overview

  • Product name

    PGP 4008, P-glycoprotein inhibitor
  • Description

    Selective P-glycoprotein inhibitor
  • Biological description

    Selective P-glycoprotein inhibitor. Reverses Pgp mediated drug resistance in NCI/ADR cells. Shows synergistic effects with doxorubicin (ab120629) in vivo.
  • Purity

    > 93%
  • CAS Number

    365565-02-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(1-Benzyl-2,3-dihydro-1H-pyrrolo[2,3-b]quinolin-4-yl)-2-phenylacetamide
  • Molecular weight

    393.49
  • Molecular formula

    C26H23N3O
  • PubChem identifier

    9821937
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 5 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN(C2=NC3=CC=CC=C3C(=C21)NC(=O)CC4=CC=CC=C4)CC5=CC=CC=C5
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Huang L  et al. P-glycoprotein expression in Perna viridis after exposure to Prorocentrum lima, a dinoflagellate producing DSP toxins. Fish Shellfish Immunol 39:254-62 (2014). Read more (PubMed: 24811006) »
  • Karla PK  et al. Molecular expression and functional evidence of a drug efflux pump (BCRP) in human corneal epithelial cells. Curr Eye Res 34:1-9 (2009). Read more (PubMed: 19172464) »
  • Lee BD  et al. Development of a syngeneic in vivo tumor model and its use in evaluating a novel P-glycoprotein modulator, PGP-4008. Oncol Res 14:49-60 (2003). Read more (PubMed: 14552591) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab145191.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up